RNA localization in Xenopus oocytes

Bruce J. Schnapp; Eric A. Arn; James O. Deshler; Martin I. Highett

doi:10.1006/scdb.1997.0178

RNA localization in Xenopus oocytes

Bruce J. Schnapp, Eric A. Arn, James O. Deshler, Martin I. Highett

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The transport and localization of mRNAs within Xenopus oocytes contributes to an asymmetry that determines axis formation in the embryo. Several mRNAs become localized along the animal-vegetal axis. The mitochondrial cloud, a specialized cytoplasmic compartment which contributes to the formation of germ plasm, and the endoplasmic reticulum play important roles in sorting and localizing these RNAs. As in other species and cell types, the localization of RNAs in Xenopus oocytes is directed by signals in the 3′ untranslated regions of the transcripts. Cytoplasmic proteins that interact with these signals are being identified, as are the links between RNA localization, intracellular organelles and early embryonic development.

Original language	English (US)
Pages (from-to)	529-540
Number of pages	12
Journal	Seminars in Cell and Developmental Biology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1006/scdb.1997.0178
State	Published - Dec 1997
Externally published	Yes

Keywords

3′untranslated region
Cell polarity
Development
Endoplasmic reticulum

ASJC Scopus subject areas

Developmental Biology
Cell Biology

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10.1006/scdb.1997.0178

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title = "RNA localization in Xenopus oocytes",

abstract = "The transport and localization of mRNAs within Xenopus oocytes contributes to an asymmetry that determines axis formation in the embryo. Several mRNAs become localized along the animal-vegetal axis. The mitochondrial cloud, a specialized cytoplasmic compartment which contributes to the formation of germ plasm, and the endoplasmic reticulum play important roles in sorting and localizing these RNAs. As in other species and cell types, the localization of RNAs in Xenopus oocytes is directed by signals in the 3′ untranslated regions of the transcripts. Cytoplasmic proteins that interact with these signals are being identified, as are the links between RNA localization, intracellular organelles and early embryonic development.",

keywords = "3′untranslated region, Cell polarity, Development, Endoplasmic reticulum",

author = "Schnapp, {Bruce J.} and Arn, {Eric A.} and Deshler, {James O.} and Highett, {Martin I.}",

note = "Funding Information: We thank Drs. Malcom Whitman, Kris Kroll and Mark Mercola for comments on the manuscript and Drs M. Kloc and L. Etkin of the University of Texas M.D. Anderson Cancer Center for providing a preprint of their work. J.O.D. was supported by post-doctoral fellowships from the NIH and the Charles A. King Trust. E.A.A. was supported by a post-doctoral fellowship from the NIH. M.I.H. was supported by a post-doctoral fellowship from the Science and Engineering Research CouncilrNorth Atlantic Treaty Organization. The NIH, the Council for Tobacco Research and the March of Dimes supported the work of B.J.S.",

year = "1997",

month = dec,

doi = "10.1006/scdb.1997.0178",

language = "English (US)",

volume = "8",

pages = "529--540",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Academic Press Inc.",

number = "6",

}

TY - JOUR

T1 - RNA localization in Xenopus oocytes

AU - Schnapp, Bruce J.

AU - Arn, Eric A.

AU - Deshler, James O.

AU - Highett, Martin I.

N1 - Funding Information: We thank Drs. Malcom Whitman, Kris Kroll and Mark Mercola for comments on the manuscript and Drs M. Kloc and L. Etkin of the University of Texas M.D. Anderson Cancer Center for providing a preprint of their work. J.O.D. was supported by post-doctoral fellowships from the NIH and the Charles A. King Trust. E.A.A. was supported by a post-doctoral fellowship from the NIH. M.I.H. was supported by a post-doctoral fellowship from the Science and Engineering Research CouncilrNorth Atlantic Treaty Organization. The NIH, the Council for Tobacco Research and the March of Dimes supported the work of B.J.S.

PY - 1997/12

Y1 - 1997/12

N2 - The transport and localization of mRNAs within Xenopus oocytes contributes to an asymmetry that determines axis formation in the embryo. Several mRNAs become localized along the animal-vegetal axis. The mitochondrial cloud, a specialized cytoplasmic compartment which contributes to the formation of germ plasm, and the endoplasmic reticulum play important roles in sorting and localizing these RNAs. As in other species and cell types, the localization of RNAs in Xenopus oocytes is directed by signals in the 3′ untranslated regions of the transcripts. Cytoplasmic proteins that interact with these signals are being identified, as are the links between RNA localization, intracellular organelles and early embryonic development.

AB - The transport and localization of mRNAs within Xenopus oocytes contributes to an asymmetry that determines axis formation in the embryo. Several mRNAs become localized along the animal-vegetal axis. The mitochondrial cloud, a specialized cytoplasmic compartment which contributes to the formation of germ plasm, and the endoplasmic reticulum play important roles in sorting and localizing these RNAs. As in other species and cell types, the localization of RNAs in Xenopus oocytes is directed by signals in the 3′ untranslated regions of the transcripts. Cytoplasmic proteins that interact with these signals are being identified, as are the links between RNA localization, intracellular organelles and early embryonic development.

KW - 3′untranslated region

KW - Cell polarity

KW - Development

KW - Endoplasmic reticulum

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DO - 10.1006/scdb.1997.0178

M3 - Article

AN - SCOPUS:0000733056

SN - 1084-9521

VL - 8

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EP - 540

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 6

ER -

RNA localization in Xenopus oocytes

Abstract

Keywords

ASJC Scopus subject areas

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