Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions

Jan Schuemann, Alexander F. Bagley, Ross Berbeco, Kyle Bromma, Karl T. Butterworth, Hilary L. Byrne, B. Devika Chithrani, Sang Hyun Cho, Jason R. Cook, Vincent Favaudon, Yaser H. Gholami, Elisabetta Gargioni, James F. Hainfeld, Félicien Hespeels, Anne Catherine Heuskin, Udoka M. Ibeh, Zdenka Kuncic, Sijumon Kunjachan, Sandrine Lacombe, Stéphane LucasFrançois Lux, Stephen McMahon, Dmitry Nevozhay, Wilfred Ngwa, J. Donald Payne, Sébastien Penninckx, Erika Porcel, Kevin M. Prise, Hans Rabus, Sharif M. Ridwan, Benedikt Rudek, Léon Sanche, Bijay Singh, Henry M. Smilowitz, Konstantin V. Sokolov, Srinivas Sridhar, Yaroslav Stanishevskiy, Wonmo Sung, Olivier Tillement, Needa Virani, Wassana Yantasee, Sunil Krishnan

Research output: Contribution to journalArticlepeer-review

81 Scopus citations


This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.

Original languageEnglish (US)
Article number21RM02
JournalPhysics in Medicine and Biology
Issue number21
StatePublished - Nov 7 2020


  • immunotherapy
  • metal nanoparticles
  • modeling
  • nanoparticle imaging
  • radiotherapy
  • theranostics
  • therapeutic applications of nanoparticles

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Roadmap for metal nanoparticles in radiation therapy: Current status, translational challenges, and future directions'. Together they form a unique fingerprint.

Cite this