TY - JOUR
T1 - Roadmap for metal nanoparticles in radiation therapy
T2 - Current status, translational challenges, and future directions
AU - Schuemann, Jan
AU - Bagley, Alexander F.
AU - Berbeco, Ross
AU - Bromma, Kyle
AU - Butterworth, Karl T.
AU - Byrne, Hilary L.
AU - Chithrani, B. Devika
AU - Cho, Sang Hyun
AU - Cook, Jason R.
AU - Favaudon, Vincent
AU - Gholami, Yaser H.
AU - Gargioni, Elisabetta
AU - Hainfeld, James F.
AU - Hespeels, Félicien
AU - Heuskin, Anne Catherine
AU - Ibeh, Udoka M.
AU - Kuncic, Zdenka
AU - Kunjachan, Sijumon
AU - Lacombe, Sandrine
AU - Lucas, Stéphane
AU - Lux, François
AU - McMahon, Stephen
AU - Nevozhay, Dmitry
AU - Ngwa, Wilfred
AU - Payne, J. Donald
AU - Penninckx, Sébastien
AU - Porcel, Erika
AU - Prise, Kevin M.
AU - Rabus, Hans
AU - Ridwan, Sharif M.
AU - Rudek, Benedikt
AU - Sanche, Léon
AU - Singh, Bijay
AU - Smilowitz, Henry M.
AU - Sokolov, Konstantin V.
AU - Sridhar, Srinivas
AU - Stanishevskiy, Yaroslav
AU - Sung, Wonmo
AU - Tillement, Olivier
AU - Virani, Needa
AU - Yantasee, Wassana
AU - Krishnan, Sunil
N1 - Publisher Copyright:
© 2020 Institute of Physics and Engineering in Medicine.
PY - 2020/11/7
Y1 - 2020/11/7
N2 - This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.
AB - This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.
KW - immunotherapy
KW - metal nanoparticles
KW - modeling
KW - nanoparticle imaging
KW - radiotherapy
KW - theranostics
KW - therapeutic applications of nanoparticles
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U2 - 10.1088/1361-6560/ab9159
DO - 10.1088/1361-6560/ab9159
M3 - Article
C2 - 32380492
AN - SCOPUS:85088559395
SN - 0031-9155
VL - 65
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
IS - 21
M1 - 21RM02
ER -