Abstract
The transcription factor E2F1 coordinates cell cycle progression and induces apoptosis in response to DNA damage stress. Aside from DNA damage, the role of E2F1 in the endoplasmic reticulum (ER) stress signaling pathways is unclear. We found that E2Fl-/- murine embryonic fibroblasts (MEFs) are resistant to apoptosis triggered by the ER stress inducer thapsigargin. In addition, E2F1 deficiency results in enhanced phosphorylation of eukaryotic translation initiation factor 2α (eIF2α). These results therefore indicate that E2F1 deficiency increases phosphorylation of eIF2α in response to ER stress triggered by thapsigargin, and suggest that the reduction in ER stress-induced apoptosis. in E2F1 deficient cells is related to the high level of eIF2α phosphorylation.
Original language | English (US) |
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Pages (from-to) | 356-359 |
Number of pages | 4 |
Journal | Molecules and Cells |
Volume | 21 |
Issue number | 3 |
State | Published - Jun 30 2006 |
Externally published | Yes |
Keywords
- E2F1
- Endoplasmic reticulum stress
- Eukaryotic translation initiation factor 2α (eIF2α)
- Thapsigargin
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology