Role of insulin-like growth factor-1R system in colorectal carcinogenesis

Erin A. Donovan; Shivaani Kummar

doi:10.1016/j.critrevonc.2007.09.003

Role of insulin-like growth factor-1R system in colorectal carcinogenesis

Erin A. Donovan, Shivaani Kummar

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy.

Original language	English (US)
Pages (from-to)	91-98
Number of pages	8
Journal	Critical Reviews in Oncology/Hematology
Volume	66
Issue number	2
DOIs	https://doi.org/10.1016/j.critrevonc.2007.09.003
State	Published - May 2008
Externally published	Yes

Keywords

Acromegaly
Anti-IGF therapy
Epidemiologic studies in cancer
Growth factors

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/j.critrevonc.2007.09.003

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title = "Role of insulin-like growth factor-1R system in colorectal carcinogenesis",

abstract = "The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy.",

keywords = "Acromegaly, Anti-IGF therapy, Epidemiologic studies in cancer, Growth factors",

author = "Donovan, {Erin A.} and Shivaani Kummar",

note = "Funding Information: This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, Bethesda, MD, United States. ",

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T1 - Role of insulin-like growth factor-1R system in colorectal carcinogenesis

AU - Donovan, Erin A.

AU - Kummar, Shivaani

N1 - Funding Information: This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research, Bethesda, MD, United States.

PY - 2008/5

Y1 - 2008/5

N2 - The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy.

AB - The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy.

KW - Acromegaly

KW - Anti-IGF therapy

KW - Epidemiologic studies in cancer

KW - Growth factors

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Role of insulin-like growth factor-1R system in colorectal carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

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