Abstract
Abstract: Rats with unilateral lesions of the locus coeruleus were used to study the role of norepinephrine (NE) signal input in the down‐regulation by antidepressants of the noradrenergic cyclic AMP‐generating system in the cortex. Chronic administration of both desipramine (blockade of NE reuptake) and iprindole (no blockade of NE reuptake) reduced the cyclic AMP response to NE on the nonlesioned side, but had little or no effect on the lesioned side. The results indicate that NE signal input and thus the formation of the NE‐receptor complex are prerequisites for inducing noradrenergic subsensitivity.
Original language | English (US) |
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Pages (from-to) | 290-292 |
Number of pages | 3 |
Journal | Journal of neurochemistry |
Volume | 39 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1982 |
Externally published | Yes |
Keywords
- Desipramine
- Iprindole
- Locus coeruleus lesions
- Norepinephrine receptor‐coupled adenylate cyclase system
- Subsensitivity to norepinephrine
ASJC Scopus subject areas
- Biochemistry
- Cellular and Molecular Neuroscience