Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function

K. A. Neve; Riad Qanbar; Michel Bouvier

doi:10.1016/S0163-7258(02)00300-5

Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function

K. A. Neve, Riad Qanbar, Michel Bouvier

Research output: Contribution to journal › Review article › peer-review

216 Scopus citations

Abstract

G-protein-coupled receptors (GPCRs) constitute one of the largest protein families in the human genome. They are subject to numerous post-translational modifications, including palmitoylation. This review highlights the dynamic nature of palmitoylation and its role in GPCR expression and function. The palmitoylation of other proteins involved in GPCR signaling, such as G-proteins, regulators of G-protein signaling, and G-protein-coupled receptor kinases, is also discussed.

Original language	English (US)
Pages (from-to)	1-33
Number of pages	33
Journal	Pharmacology and Therapeutics
Volume	97
Issue number	1
DOIs	https://doi.org/10.1016/S0163-7258(02)00300-5
State	Published - Jan 1 2003
Externally published	Yes

Keywords

G-protein-coupled receptors (GPCRs)
G-proteins
Palmitoylation
Signaling

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1016/S0163-7258(02)00300-5

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abstract = "G-protein-coupled receptors (GPCRs) constitute one of the largest protein families in the human genome. They are subject to numerous post-translational modifications, including palmitoylation. This review highlights the dynamic nature of palmitoylation and its role in GPCR expression and function. The palmitoylation of other proteins involved in GPCR signaling, such as G-proteins, regulators of G-protein signaling, and G-protein-coupled receptor kinases, is also discussed.",

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AB - G-protein-coupled receptors (GPCRs) constitute one of the largest protein families in the human genome. They are subject to numerous post-translational modifications, including palmitoylation. This review highlights the dynamic nature of palmitoylation and its role in GPCR expression and function. The palmitoylation of other proteins involved in GPCR signaling, such as G-proteins, regulators of G-protein signaling, and G-protein-coupled receptor kinases, is also discussed.

KW - G-protein-coupled receptors (GPCRs)

KW - G-proteins

KW - Palmitoylation

KW - Signaling

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Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function

Abstract

Keywords

ASJC Scopus subject areas

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