Roles of the Hu/ELAV Family of mRNA-Stabilizing Proteins in Tumor Development

Cyril Sobolewski; Sahida Afroz; Samantha Z. Brown; Jonathan R. Brody; Dan A. Dixon

doi:10.1142/9789811248665_0005

Roles of the Hu/ELAV Family of mRNA-Stabilizing Proteins in Tumor Development

Cyril Sobolewski, Sahida Afroz, Samantha Z. Brown, Jonathan R. Brody, Dan A. Dixon

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The Hu/ELAV family of RNA-binding proteins consists of the members HuR, HuB, HuC, and HuD (ELAVL1, ELAVL2, ELAVL3, ELAVL4, respectively). These factors contribute to a variety of physiological and pathological processes, primarily dependent on the cell/tissue type they are expressed. HuB, HuC, and HuD are mainly expressed in neuronal tissues and play a role in neuronal development and differentiation, whereas HuR is ubiquitously expressed and has various functions in multiple organ systems. Through their ability to recognize and bind many target mRNAs, Hu/ELAV proteins modulate gene expression through post-transcriptional regulation impacting mRNA stability and translation. In the context of cancer, the role of HuR as a tumor-promoting factor has been demonstrated in several organ types with higher expression observed in most human cancers. In this chapter, we focus on the role Hu/ELAV proteins in human cancer with an emphasis on the role of HuR in promoting altered gene expression contributing to cancer hallmarks.

Original language	English (US)
Title of host publication	Rna-based Mechanisms in Cancer
Publisher	World Scientific Publishing Co.
Pages	135-160
Number of pages	26
ISBN (Electronic)	9789811248665
ISBN (Print)	9789811248658
DOIs	https://doi.org/10.1142/9789811248665_0005
State	Published - Jan 1 2023

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Medicine

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abstract = "The Hu/ELAV family of RNA-binding proteins consists of the members HuR, HuB, HuC, and HuD (ELAVL1, ELAVL2, ELAVL3, ELAVL4, respectively). These factors contribute to a variety of physiological and pathological processes, primarily dependent on the cell/tissue type they are expressed. HuB, HuC, and HuD are mainly expressed in neuronal tissues and play a role in neuronal development and differentiation, whereas HuR is ubiquitously expressed and has various functions in multiple organ systems. Through their ability to recognize and bind many target mRNAs, Hu/ELAV proteins modulate gene expression through post-transcriptional regulation impacting mRNA stability and translation. In the context of cancer, the role of HuR as a tumor-promoting factor has been demonstrated in several organ types with higher expression observed in most human cancers. In this chapter, we focus on the role Hu/ELAV proteins in human cancer with an emphasis on the role of HuR in promoting altered gene expression contributing to cancer hallmarks.",

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AU - Sobolewski, Cyril

AU - Afroz, Sahida

AU - Brown, Samantha Z.

AU - Brody, Jonathan R.

AU - Dixon, Dan A.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - The Hu/ELAV family of RNA-binding proteins consists of the members HuR, HuB, HuC, and HuD (ELAVL1, ELAVL2, ELAVL3, ELAVL4, respectively). These factors contribute to a variety of physiological and pathological processes, primarily dependent on the cell/tissue type they are expressed. HuB, HuC, and HuD are mainly expressed in neuronal tissues and play a role in neuronal development and differentiation, whereas HuR is ubiquitously expressed and has various functions in multiple organ systems. Through their ability to recognize and bind many target mRNAs, Hu/ELAV proteins modulate gene expression through post-transcriptional regulation impacting mRNA stability and translation. In the context of cancer, the role of HuR as a tumor-promoting factor has been demonstrated in several organ types with higher expression observed in most human cancers. In this chapter, we focus on the role Hu/ELAV proteins in human cancer with an emphasis on the role of HuR in promoting altered gene expression contributing to cancer hallmarks.

AB - The Hu/ELAV family of RNA-binding proteins consists of the members HuR, HuB, HuC, and HuD (ELAVL1, ELAVL2, ELAVL3, ELAVL4, respectively). These factors contribute to a variety of physiological and pathological processes, primarily dependent on the cell/tissue type they are expressed. HuB, HuC, and HuD are mainly expressed in neuronal tissues and play a role in neuronal development and differentiation, whereas HuR is ubiquitously expressed and has various functions in multiple organ systems. Through their ability to recognize and bind many target mRNAs, Hu/ELAV proteins modulate gene expression through post-transcriptional regulation impacting mRNA stability and translation. In the context of cancer, the role of HuR as a tumor-promoting factor has been demonstrated in several organ types with higher expression observed in most human cancers. In this chapter, we focus on the role Hu/ELAV proteins in human cancer with an emphasis on the role of HuR in promoting altered gene expression contributing to cancer hallmarks.

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PB - World Scientific Publishing Co.

ER -

Roles of the Hu/ELAV Family of mRNA-Stabilizing Proteins in Tumor Development

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