Abstract
Distinctive cytoplasmic alterations of Schwann cells were observed by electron microscopy in rats and mice with peripheral neuropathy induced by chronic exposure to 2,5-hexanedione. Pronounced enlargement of Schwann cells was due to accumulation of 100 Å cytoplasmic filaments and endoplasmic reticulum and was most often observed after 12-15 weeks exposure to 2,5-hexanedione. Examination of teased nerve fibres revealed segmental demyelination and remyelination involving axons of normal diameter as well as giant axons. The filament disorder induced by 2,5-hexanedione administration is not limited solely to axoplasmic contents. Possible mechanisms of demyelination are discussed and the changes are compared to those observed in human neuropathy for which 2,5-hexanedione appears to be the closest experimental model.
Original language | English (US) |
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Pages (from-to) | 517-528 |
Number of pages | 12 |
Journal | Journal of Neurocytology |
Volume | 7 |
Issue number | 4 |
DOIs | |
State | Published - Aug 1978 |
Externally published | Yes |
ASJC Scopus subject areas
- Anatomy
- General Neuroscience
- Histology
- Cell Biology