Abstract
New BODIPY-based pH probes have been designed with excitation and emission wavelengths suitable for fluorescence microscopy and flow cytometry. These pH probes are cell-permeable, selectively label lysosomes, and can be used for noninvasive monitoring of lysosomal pH changes during physiological and pathological processes.
Original language | English (US) |
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Pages (from-to) | 3546-3549 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 21 |
Issue number | 12 |
DOIs | |
State | Published - Jun 15 2011 |
Externally published | Yes |
Keywords
- Cell imaging
- Confocal microscopy
- Fluorescent probe
- Lysosome
- pH sensor
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry