Serum Lysozyme in Mice with Induced Granulomas

To the Editor: Last year, Falchuk, Perrotto, and Isselbacher presented evidence that the concentration of lysozyme in the serum was elevated in patients with Crohn's disease and normal in ulcerative colitis¹and that the degree of elevation was related to activity of the disease.²Most other investigators have failed to corroborate these findings.^{3 4 5 6 7 8}although one study using the turbidimetric method for the enzyme measurement has indicated that an elevated level was suggestive of Crohn's disease.⁹The stimulus for the initial study was based upon the fact that monocytes secrete lysozyme and that diseases in which active tissue granulomas occur,. . .