Serum müllerian-inhibiting substance in Down's syndrome pregnancies

David B. Seifer, David T. MacLaughlin, Howard S. Cuckle

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


BACKGROUND: To examine whether maternal serum levels of müllerian-inhibiting substance (MIS) differ in Down's syndrome and unaffected pregnancies. METHODS: Case-control study was conducted using stored serum from an antenatal screening programme. Sera from 25 Down's syndrome pregnancies were retrieved from -20°C storage together with 125 unaffected controls individually matched for maternal age, weeks of gestation and duration of storage. Results were expressed in multiples of the gestation-specific median value (MoM) in controls. RESULTS: The median value in Down's syndrome pregnancies was 0.83 MoM (P = 0.77, two-tail Wilcoxon rank sum test). Among unaffected pregnancies, there was a statistically significant correlation between MIS and pregnancy-associated plasma protein-A (P < 0.05). MIS levels were elevated in pregnancies where assisted reproduction techniques had been used. CONCLUSION: There is no evidence for a substantial reduction in maternal serum MIS levels in Down's syndrome pregnancies. This study provides useful information regarding serum MIS levels in pregnancy.

Original languageEnglish (US)
Pages (from-to)1017-1020
Number of pages4
JournalHuman Reproduction
Issue number4
StatePublished - Apr 2007
Externally publishedYes


  • Antenatal screening
  • Down's syndrome
  • MIS
  • Marker
  • Ovarian reserve

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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