@article{339fc08bc5a44202b132d58840dbbe63,
title = "Seven newly identified loci for autoimmune thyroid disease",
abstract = "Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10-6; a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases.",
author = "{Wellcome Trust Case Control Consortium} and Cooper, {Jason D.} and Simmonds, {Matthew J.} and Walker, {Neil M.} and Oliver Burren and Brand, {Oliver J.} and Hui Guo and Chris Wallace and Helen Stevens and Gillian Coleman and Franklyn, {Jayne A.} and Todd, {John A.} and Gough, {Stephen C.L.} and Jan Aerts and Tariq Ahmad and Hazel Arbury and Anthony Attwood and Adam Auton and Ball, {Stephen G.} and Balmforth, {Anthony J.} and Chris Barnes and Barrett, {Jeffrey C.} and In{\^e}s Barroso and Anne Barton and Bennett, {Amanda J.} and Sanjeev Bhaskar and Katarzyna Blaszczyk and John Bowes and Braund, {Peter S.} and Francesca Bredin and Gerome Breen and Brown, {Morris J.} and Bruce, {Ian N.} and Jaswinder Bull and John Burton and Jake Byrnes and Sian Caesar and Niall Cardin and Clee, {Chris M.} and Coffey, {Alison J.} and Connell, {John M.C.} and Conrad, {Donald F.} and Dominiczak, {Anna F.} and Kate Downes and Drummond, {Hazel E.} and Darshna Dudakia and Andrew Dunham and Bernadette Ebbs and Diana Eccles and Sarah Edkins and Cathryn Edwards",
note = "Funding Information: We would like to thank all AITD patients and control subjects for participating in this study. We thank nurses and doctors for recruiting AITD patients into the AITD National Collection. We thank the members of each disease consortium who initiated and sustained the cross-disease ImmunoChip project. We thank Jeffrey Barrett for assistance with ImmunoChip SNP selection and for ImmunoChip-related correspondence. We thank Jenni-fer Stone for co-ordinating the ImmunoChip design and production at Illumina. The authors wish to acknowledge Sarah Edkins, Emma Gray, Doug Simpkin, Sarah Hunt and staff of the Sanger Institute{\textquoteright}s Sample Logistics, Genotyping and Variation Informatics facilities, respectively. The Diabetes and Inflammation Laboratory is funded by the Juvenile Diabetes Research Foundation International, the Wellcome Trust and the National Institute for Health Research Cambridge Biomedical Centre. The Cambridge Institute for Medical Research (CIMR) is in receipt of a Wellcome Trust Strategic Award (079895). Core infrastructure support to the Wellcome Trust Centre for Human Genetics, Oxford was provided by grant 090532/Z/09/Z. The WTCCC is funded by Wellcome Trust awards 076113 and 083948. CW is supported by the Wellcome Trust (089989). We acknowledge use of DNA from The UK Blood Services collection of Common Controls (UKBS-CC collection), which is funded by the Wellcome Trust grant 076113/C/04/Z and by the USA National Institute for Health Research program grant to the National Health Service Blood and Transplant (RP-PG-0310-1002). We acknowledge the use of DNA from the British 1958 Birth Cohort collection, which is funded by the UK Medical Research Council grant G0000934 and the Wellcome Trust grant 068545/Z/02. This research utilized resources provided by the Type 1 Diabetes Genetics Consortium, a collaborative clinical study sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Allergy and Infectious Diseases, the National Human Genome Research Institute, the National Institute of Child Health and Human Development and the Juvenile Diabetes Research Foundation International and is supported by the USA National Institutes of Health grant U01-DK062418. Funding Information: The research leading to these results has received funding from the European Union{\textquoteright}s 7th Framework Programme (FP7/2007 – 2013) under grant agreement No. 241447 [Natural immunomodulators as novel immunotherapies for type 1 diabetes (NAIMIT)]. Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust.",
year = "2012",
month = dec,
day = "1",
doi = "10.1093/hmg/dds357",
language = "English (US)",
volume = "21",
pages = "5202--5208",
journal = "Human molecular genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "23",
}