Sex differences in the corpus callosum with aging

D. Salat, A. Ward, J. A. Kaye, Jeri S. Janowsky

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


The present study examined sex differences in the area and age-related atrophy of the corpus callosum (CC) of 76 healthy elderly subjects using magnetic resonance imaging. The cerebellum and pons served as noncortical control structures. CC area and its subregions were also related to cognitive performance. Women had a slightly larger posterior sector of the CC than men. Women but not men showed age-related atrophy of the anterior and middle sectors of the CC but not the posterior sector. Cerebellum and pons size was similar in men and women, and neither showed age-related atrophy. CC area was related to visual memory in women but not men; no other significant cognitive to structure area relationships were found. These findings show that selective age related atrophy of the CC differs in men and women late in life.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalNeurobiology of Aging
Issue number2
StatePublished - 1997


  • Aged
  • Aging
  • Corpus callosum
  • Human
  • Magnetic resonance imaging
  • Neuropsychological tests
  • Sex characteristics
  • Visual memory

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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