Sexual differentiation of the brain

C. E. Roselli

doi:10.1016/B978-0-12-809324-5.03436-2

Sexual differentiation of the brain

C. E. Roselli

Chemical Physiology and Biochemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

In male vertebrates, perinatal exposure to testosterone is both necessary and sufficient to masculinize tonic gonadotropin secretion and copulatory behavior. In contrast, females develop in the absence of high steroid exposure and express cyclic gonadotropin secretion and receptive behaviors. The cellular and molecular processes by which testosterone acts to organize sex specific brain functions are complex and can be modified by social and environmental factors. Studies of humans with clinical syndromes in which fetuses are exposed too much or too little androgen provide support that sex hormones also influence sexual differentiation of the human brain and behavior.

Original language	English (US)
Title of host publication	The Curated Reference Collection in Neuroscience and Biobehavioral Psychology
Publisher	Elsevier Science Ltd.
Pages	356-362
Number of pages	7
ISBN (Electronic)	9780128093245
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.03436-2
State	Published - Jan 1 2016

Keywords

Anteroventral periventricular preoptic nucleus
Aromatase
Critical period
Estradiol
Medial preoptic area
Sex differences
Sexual differentiation
Sexual dimorphism
Sexually dimorphic nucleus
Spinal nucleus of the bulbocarernosus
Testosterone
Third interstitial nucleus of the anterior hypothalamus

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-12-809324-5.03436-2

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abstract = "In male vertebrates, perinatal exposure to testosterone is both necessary and sufficient to masculinize tonic gonadotropin secretion and copulatory behavior. In contrast, females develop in the absence of high steroid exposure and express cyclic gonadotropin secretion and receptive behaviors. The cellular and molecular processes by which testosterone acts to organize sex specific brain functions are complex and can be modified by social and environmental factors. Studies of humans with clinical syndromes in which fetuses are exposed too much or too little androgen provide support that sex hormones also influence sexual differentiation of the human brain and behavior.",

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ER -

Sexual differentiation of the brain

Abstract

Keywords

ASJC Scopus subject areas

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