Sexual Precocity With Hypothalamic Hypopituitarism

Stephen H. Lafranchi

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Two girls, one with septo-optic dysplasia and the other with posttraumatic brain damage, had the unusual combination of human growth hormone, thyrotropin, adrenocorticotrophic hormone, and vasopressin deficiencies that were associated with sexual precocity in one patient and early sexual maturation in the second patient, and of adult follicle-stimulating hormone and luteinizing hormone concentrations. At autopsy, the first patient had optic nerve aplasia, a normal pituitary gland, and some disorganization of myelinated fibers in the hypothalamus. The second patient had a normal thyrotropin and prolactin response to thyrotropin-releasing hormone, plus hyperphagia, deranged thirst mechanism, and temperature instability. These findings suggest that the lesion may be a defective hypothalamic regulation of pituitary hormone secretion. Congenital or traumatic hypothalamic-pituitary lesions may not affect all releasing factors or trophic hormones in a similar fashion. (Am J Dis Child 133:739-742, 1979.

Original languageEnglish (US)
Pages (from-to)739-742
Number of pages4
JournalAmerican Journal of Diseases of Children
Issue number7
StatePublished - Jul 1979

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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