SGK1: A rapid aldosterone-induced regulator of renal sodium reabsorption

James A. McCormick, Vivek Bhalla, Alan C. Pao, David Pearce

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations


Recently, substantial progress has been made in understanding the mechanisms by which aldosterone rapidly stimulates sodium transport in the distal nephron and other tight epithelia. Serum- and glucocorticoid-regulated kinase 1 (SGK1) has been identified as an important mediator of this process. Its physiological relevance has been revealed through heterologous expression in cultured cells and generation of SGK1 knockout mice.

Original languageEnglish (US)
Pages (from-to)134-139
Number of pages6
Issue number2
StatePublished - Apr 2005
Externally publishedYes

ASJC Scopus subject areas

  • Physiology


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