Single-shot OCT and OCT angiography for slab-specific detection of diabetic retinopathy

Guangru B. Liang; Tristan T. Hormel; Xiang Wei; Yukun Guo; Jie Wang; Thomas Hwang; Yali Jia

doi:10.1364/BOE.503476

Single-shot OCT and OCT angiography for slab-specific detection of diabetic retinopathy

Guangru B. Liang, Tristan T. Hormel, Xiang Wei, Yukun Guo, Jie Wang, Thomas Hwang, Yali Jia

Ophthalmology

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, we present an optical coherence tomographic angiography (OCTA) prototype using a 500 kHz high-speed swept-source laser. This system can generate a 75-degree field of view with a 10.4 µm lateral resolution with a single acquisition. With this prototype we acquired detailed, wide-field, and plexus-specific images throughout the retina and choroid in eyes with diabetic retinopathy, detecting early retinal neovascularization and locating pathology within specific retinal slabs. Our device could also visualize choroidal flow and identify signs of key biomarkers in diabetic retinopathy.

Original language	English (US)
Pages (from-to)	5682-5695
Number of pages	14
Journal	Biomedical Optics Express
Volume	14
Issue number	11
DOIs	https://doi.org/10.1364/BOE.503476
State	Published - Nov 2023

ASJC Scopus subject areas

Biotechnology
Atomic and Molecular Physics, and Optics

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abstract = "In this study, we present an optical coherence tomographic angiography (OCTA) prototype using a 500 kHz high-speed swept-source laser. This system can generate a 75-degree field of view with a 10.4 µm lateral resolution with a single acquisition. With this prototype we acquired detailed, wide-field, and plexus-specific images throughout the retina and choroid in eyes with diabetic retinopathy, detecting early retinal neovascularization and locating pathology within specific retinal slabs. Our device could also visualize choroidal flow and identify signs of key biomarkers in diabetic retinopathy.",

author = "Liang, {Guangru B.} and Hormel, {Tristan T.} and Xiang Wei and Yukun Guo and Jie Wang and Thomas Hwang and Yali Jia",

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AU - Liang, Guangru B.

AU - Hormel, Tristan T.

AU - Wei, Xiang

AU - Guo, Yukun

AU - Wang, Jie

AU - Hwang, Thomas

AU - Jia, Yali

PY - 2023/11

Y1 - 2023/11

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AB - In this study, we present an optical coherence tomographic angiography (OCTA) prototype using a 500 kHz high-speed swept-source laser. This system can generate a 75-degree field of view with a 10.4 µm lateral resolution with a single acquisition. With this prototype we acquired detailed, wide-field, and plexus-specific images throughout the retina and choroid in eyes with diabetic retinopathy, detecting early retinal neovascularization and locating pathology within specific retinal slabs. Our device could also visualize choroidal flow and identify signs of key biomarkers in diabetic retinopathy.

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Single-shot OCT and OCT angiography for slab-specific detection of diabetic retinopathy

Abstract

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