Sleep dysfunction and inflammatory bowel disease

M. Anthony Sofia, Michael Andersen, David T. Rubin

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Inflammatory bowel disease (IBD) is a complex inflammatory condition due to an altered immune response to host and environmental stimuli. Numerous pathways are involved in the upregulation of cytokines and chemokines that can promote inflammation and clinical disease activity. The effect of sleep and the regulatory effect of normal circadian rhythms on inflammatory homeostasis have been of increased interest in IBD. This chapter will review the complex interrelationship between sleep physiology and IBD, and will highlight the role of sleep as a potential target for clinicians to optimize IBD management.

Original languageEnglish (US)
Title of host publicationSleep Effect on Gastrointestinal Health and Disease
Subtitle of host publicationTranslational Opportunities for Promoting Health and Optimizing Disease Management
PublisherNova Science Publishers, Inc.
Number of pages23
ISBN (Electronic)9781536133608
ISBN (Print)9781536133592
StatePublished - Jan 1 2018
Externally publishedYes


  • Chemokines
  • Cytokines
  • Inflammatory bowel disease
  • Sleep disorders

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)


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