Smoking, obesity, and survival in squamous cell carcinoma of the vulva

Carolyn V. Kirschner, Edgardo L. Yordan, Koen De Geest, George D. Wilbanks

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


One hundred thirty-six patients with invasive squamous cell carcinoma of the vulva were studied retrospectively to determine prognostic factors for survival. In the regression analysis, three variables were statistically significantly related to survival: smoking history, tumor size, and node status. Smokers had a 6.3 times greater risk of death than nonsmokers, node positivity imparted an 8.3 times greater risk than node negativity, and for each 1-cm increase in the size of the tumor, the risk of death increased by 46%. A relative decrease in survival in smokers was observed, despite a younger age and fewer positive nodes at diagnosis compared to nonsmokers. Increased surveillance in these patients may be warranted.

Original languageEnglish (US)
Pages (from-to)79-84
Number of pages6
JournalGynecologic oncology
Issue number1
StatePublished - Jan 1995
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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