Sodium channels in the axolemma of unmyelinated axons: a new estimate

R. G. Pellegrino; P. S. Spencer; J. M. Ritchie

doi:10.1016/0006-8993(84)90442-6

Sodium channels in the axolemma of unmyelinated axons: a new estimate

R. G. Pellegrino, P. S. Spencer, J. M. Ritchie

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The saturable uptake of tritium-labeled saxitoxin by the rat left cervical sympathetic trunk, which consists almost entirely of unmyelinated fibers, indicates that the density of sodium channels on the axolemma of these fibers is about 200 channels/μm².

Original language	English (US)
Pages (from-to)	357-360
Number of pages	4
Journal	Brain research
Volume	305
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)90442-6
State	Published - Jul 9 1984
Externally published	Yes

Keywords

excitable tissue
mammalian cervical sympathetic trunk
saxitoxin binding
sodium channels
ultrastructure
unmyelinated axons

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(84)90442-6

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title = "Sodium channels in the axolemma of unmyelinated axons: a new estimate",

abstract = "The saturable uptake of tritium-labeled saxitoxin by the rat left cervical sympathetic trunk, which consists almost entirely of unmyelinated fibers, indicates that the density of sodium channels on the axolemma of these fibers is about 200 channels/μm2.",

keywords = "excitable tissue, mammalian cervical sympathetic trunk, saxitoxin binding, sodium channels, ultrastructure, unmyelinated axons",

author = "Pellegrino, {R. G.} and Spencer, {P. S.} and Ritchie, {J. M.}",

note = "Funding Information: We would like to thank Rita M. Pellegrino, Richard Robertson and Louise Tedesco for their technical assistance. This work was supported in part by Grants NS08304, NS12327, NS13106, NS19611, and T32GM7288 from the USPHS and by Grant RG 1162 from the National Multiple Sclerosis Society.",

year = "1984",

month = jul,

day = "9",

doi = "10.1016/0006-8993(84)90442-6",

language = "English (US)",

volume = "305",

pages = "357--360",

journal = "Brain research",

issn = "0006-8993",

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number = "2",

}

TY - JOUR

T1 - Sodium channels in the axolemma of unmyelinated axons

T2 - a new estimate

AU - Pellegrino, R. G.

AU - Spencer, P. S.

AU - Ritchie, J. M.

N1 - Funding Information: We would like to thank Rita M. Pellegrino, Richard Robertson and Louise Tedesco for their technical assistance. This work was supported in part by Grants NS08304, NS12327, NS13106, NS19611, and T32GM7288 from the USPHS and by Grant RG 1162 from the National Multiple Sclerosis Society.

PY - 1984/7/9

Y1 - 1984/7/9

N2 - The saturable uptake of tritium-labeled saxitoxin by the rat left cervical sympathetic trunk, which consists almost entirely of unmyelinated fibers, indicates that the density of sodium channels on the axolemma of these fibers is about 200 channels/μm2.

AB - The saturable uptake of tritium-labeled saxitoxin by the rat left cervical sympathetic trunk, which consists almost entirely of unmyelinated fibers, indicates that the density of sodium channels on the axolemma of these fibers is about 200 channels/μm2.

KW - excitable tissue

KW - mammalian cervical sympathetic trunk

KW - saxitoxin binding

KW - sodium channels

KW - ultrastructure

KW - unmyelinated axons

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U2 - 10.1016/0006-8993(84)90442-6

DO - 10.1016/0006-8993(84)90442-6

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AN - SCOPUS:0021237099

SN - 0006-8993

VL - 305

SP - 357

EP - 360

JO - Brain research

JF - Brain research

IS - 2

ER -

Sodium channels in the axolemma of unmyelinated axons: a new estimate

Abstract

Keywords

ASJC Scopus subject areas

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