@inbook{70677d40c4fc44e4ab057dbd644ce8d0,
title = "Soluble guanylyl cyclases in invertebrates: Targets for NO and O2",
abstract = "The major cellular targets for NO are soluble guanylyl cyclases (sGCs), which are activated upon binding NO and catalyse the synthesis of cyclic guanosine monophosphate (GMP). Invertebrates and possibly vertebrates have two families of sGCs: conventional NO-sensitive sGCs, and atypical sGCs that are insensitive to NO. Recent evidence suggests that the atypical sGCs act as oxygen sensors, mediating behavioral responses to oxygen content in the environment. Here we review the biochemical properties of both families of sGCs and recent evidence supporting the model that atypical sGCs can act as molecular oxygen sensors.",
keywords = "Drosophila melanogaster, cGMP, heme proteins, hypoxia, signaling.",
author = "Morton, {David B.} and Anke Vermehren",
note = "Funding Information: This work was supported by NIH grant NS29740.",
year = "2007",
doi = "10.1016/S1872-2423(07)01003-4",
language = "English (US)",
isbn = "9780444531193",
series = "Advances in Experimental Biology",
pages = "65--82",
editor = "Bruno Tota and Barry Trimmer",
booktitle = "Nitric Oxide",
}