Soluble guanylyl cyclases in invertebrates: Targets for NO and O2

David B. Morton, Anke Vermehren

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


The major cellular targets for NO are soluble guanylyl cyclases (sGCs), which are activated upon binding NO and catalyse the synthesis of cyclic guanosine monophosphate (GMP). Invertebrates and possibly vertebrates have two families of sGCs: conventional NO-sensitive sGCs, and atypical sGCs that are insensitive to NO. Recent evidence suggests that the atypical sGCs act as oxygen sensors, mediating behavioral responses to oxygen content in the environment. Here we review the biochemical properties of both families of sGCs and recent evidence supporting the model that atypical sGCs can act as molecular oxygen sensors.

Original languageEnglish (US)
Title of host publicationNitric Oxide
EditorsBruno Tota, Barry Trimmer
Number of pages18
StatePublished - 2007

Publication series

NameAdvances in Experimental Biology
ISSN (Print)1872-2423


  • Drosophila melanogaster
  • cGMP
  • heme proteins
  • hypoxia
  • signaling.

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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