Abstract
Addition of a benzyl substituent to the macrocyclic ring of DOTA has a substantial impact on the conformational ring flipping motion of the macrocycle in the resulting LnDOTA complexes. The p-NO2-benzyl substituent in the Ln(p-NO2-Bn-DOTA)- complexes lies in an equatorial position and effectively "locks" the conformation of the ring into the δδδδ configuration. The presence of the p-NO 2-benzyl group also increases the population of the square antiprismatic (SAP) coordination isomer for all Ln(p-NO 2-Bn-DOTA)- complexes relative to that seen for the respective LnDOTA- complexes. Despite this increase in SAP isomer population, the rate of water exchange in these complexes remains comparatively fast. The kinetic and thermodynamic stabilities of the Ln(p-NO 2-Bn-DOTA)- complexes are also slightly lower than the corresponding LnDOTA- complexes but appear to be sufficiently high for in vivo use.
Original language | English (US) |
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Pages (from-to) | 2845-2851 |
Number of pages | 7 |
Journal | Inorganic Chemistry |
Volume | 43 |
Issue number | 9 |
DOIs | |
State | Published - May 3 2004 |
Externally published | Yes |
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Inorganic Chemistry