Somatomedin C in treated acromegaly: Poor correlation with growth hormone and clinical response

Larry D. Stonesifer, Richard M. Jordan, Peter O. Kohler

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


To determine the usefulness of commercially available somatomedin C levels in the evaluation of the treatment of acromegaly, 15 patients were tested at 0.25-15.4 yr after onset of therapy. Clinical response, as determined by a numerical scoring system, was compared with RIA of GH and somatomedin C. Symptomatic response was poorly correlated with somatomedin C (r = 0.033) as well as with GH (r = 0.24). The correlation of GH and somatomedin C was also poor (r = 0.46, P > 0.05). Eighty-three percent of patients with clinical improvement had GH less than or equal to 10 ng/ml, 50% had GH less than or equal to 5 ng/ml, while 42% had somatomedin C less than or equal to 3.0 U/ml. All patients who were evaluated at 1 yr or less after therapy had elevated somatomedin C levels with normal or near normal GH values. In contrast only 2 of 11 patients evaluated at more than 1 yr after therapy had a mild persistence of somatomedin C elevation with normal GH levels. Determination of somatomedin C costs more than GH determinations and appears to offer no apparent advantage over GH in following patients treated for acromegaly.

Original languageEnglish (US)
Pages (from-to)931-934
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number5
StatePublished - Nov 1981
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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