Special Senses: Eye

Piper M. Treuting, Rachel Wong, Daniel C. Tu, Isabella Phan

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations


The mammalian eye is similar between mice and humans, with most gross and histologic differences due to relative sizing. Fixation of the eye and the retina in particular can be challenging due to poor penetration of fixatives through the sclera. In addition, routine formalin fixation can impart numerous artifacts, including separation of the retinal pigment epithelium from the outer segment of the retina. The average adult mouse eye is approximately 4 mm in diameter. The human eye measures 23.5-25 mm in diameter. In both species, the outer layer of the eye provides structural integrity and consists anteriorly of the optically clear cornea and posteriorly of the opaque sclera. The transition zone between the cornea and sclera is termed the limbus. Posterior to the limbus, the eye consists of three main layers (from external to internal): sclera, uvea, and retina. The space within the eye can be subdivided into three compartments: the anterior chamber, the posterior chamber, and the vitreous cavity. © 2012

Original languageEnglish (US)
Title of host publicationComparative Anatomy and Histology
PublisherElsevier Inc.
Number of pages24
ISBN (Print)9780123813619
StatePublished - 2012
Externally publishedYes


  • Anatomy
  • Conjunctiva
  • Cornea
  • Eye
  • Harderian gland
  • Histology
  • Human
  • Iris
  • Lacrimal gland
  • Lens
  • Mouse
  • Retina
  • Sclera

ASJC Scopus subject areas

  • General Dentistry
  • General Medicine


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