Abstract
The mammalian eye is similar between rodents and humans, with most gross and histological differences due to relative sizing. Fixation of the eye and the retina in particular can be challenging due to poor penetration of fixatives through the sclera. In addition, routine formalin fixation can impart numerous artifacts, including separation of the retinal pigment epithelium from the outer segment of the retina. Davidson’s fixative provides excellent preservation of the retina but is not commonly used by most investigators. Therefore, except where noted, the mouse tissues in this chapter were fixed with 10% neutral buffered formalin.
Original language | English (US) |
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Title of host publication | Comparative Anatomy and Histology |
Subtitle of host publication | A Mouse, Rat, and Human Atlas, Second Edition |
Publisher | Elsevier |
Pages | 445-470 |
Number of pages | 26 |
ISBN (Electronic) | 9780128029008 |
ISBN (Print) | 9780128029190 |
DOIs | |
State | Published - Jan 1 2017 |
Keywords
- Eye
- Harderian gland
- anatomy
- conjunctiva
- cornea
- histology
- human
- iris
- lacrimal gland
- lens
- mouse
- retina
- sclera
ASJC Scopus subject areas
- General Medicine