Specificity of Regulatory CD4+CD25+ T Cells for Self-T Cell Receptor Determinants

Abigail C. Buenafe, Laura Tsaknaridis, Leslie Spencer, Kevin S. Hicks, Rachel H. McMahan, Lisa Watson, Nicole E. Culbertson, Dorian Latocha, Keith Wegmann, Tom Finn, Richard Bartholomew, Gregory G. Burrows, Ruth Whitham, Dennis N. Bourdette, Richard E. Jones, Halina Offner, Yuan K. Chou, Arthur A. Vandenbark

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Although the phenotypic and regulatory properties of the CD4 +CD25+ T cell lineage (Treg cells) have been well described, the specificities remain largely unknown. We demonstrate here that the CD4+CD25+ Treg population includes the recognition of a broad spectrum of human TCR CDR2 determinants found in the germline V gene repertoire as well as that of a clonotypic nongermline-encoded CDR3β sequence present in a recombinant soluble T cell receptor (TCR) protein. Regulatory activity was demonstrated in T cell lines responsive to TCR but not in T cell lines responsive to control antigens. Inhibitory activity of TCR-reactive T cells required cell-cell contact and involved CTLA-4, GITR, IL-10, and IL-17. Thus, the T-T regulatory network includes Treg cells with specificity directed toward self-TCR determinants.

Original languageEnglish (US)
Pages (from-to)129-140
Number of pages12
JournalJournal of Neuroscience Research
Issue number1
StatePublished - Apr 1 2004


  • Autoimmunity
  • Multiple sclerosis
  • Regulatory T cells
  • Suppression
  • T cell receptor

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience


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