TY - JOUR
T1 - Spectrum of 68Ga-DOTA TATE Uptake in Patients With Neuroendocrine Tumors
AU - Moradi, Farshad
AU - Jamali, Mehran
AU - Barkhodari, Amir
AU - Schneider, Bernadette
AU - Chin, Frederick
AU - Quon, Andrew
AU - Mittra, Erik S.
AU - Iagaru, Andrei
N1 - Publisher Copyright:
© 2015 Wolters Kluwer Health, Inc.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Purpose To analyze the biodistribution of 68 Ga-DOTA-TATE in the normal tissues and uptake in benign, indeterminate, and malignant lesions in a population of patients with known neuroendocrine tumors (NET) using semiquantitative standardized uptake values (SUV) measurements. Methods One hundred four consecutively scanned patients (51 men and 53 women; mean age, 56.4 years) with confirmed diagnosis of NET underwent PET/CT 1 hour after administration of 68 Ga-DOTA-TATE. SUV mean, and SUV max were measured in 37 normal anatomical structures for each patient. Abnormal uptake was divided into benign, indeterminate, and malignant categories based on imaging characteristic, clinical follow-up, and pathology. Results High physiologic uptake (SUV max > 7) was observed in spleen, renal parenchyma, adrenal glands, pituitary gland, stomach, and liver (in decreasing order). Moderate uptake (3.5-7) was present in the prostate, jejunum, pancreas, ileum, and salivary glands. Mild uptake (2-3.5) was present in the uterus, colon, thyroid, rectum, and skeleton. A total of 678 lesions (limited to 5 lesions with highest uptake per organ) were included in the analysis, including 127 benign and 54 indeterminate lesions. Uptake was significantly higher in malignant lesions than in benign lesions, but an overlap was noted between the groups. Conclusions 68 Ga-DOTA TATE uptake in normal and abnormal structures is highly variable in patients with NET. SUV is a useful measure for characterizing benign versus malignant lesions. Anatomical and clinical correlation may be necessary to characterize foci of intermediate uptake.
AB - Purpose To analyze the biodistribution of 68 Ga-DOTA-TATE in the normal tissues and uptake in benign, indeterminate, and malignant lesions in a population of patients with known neuroendocrine tumors (NET) using semiquantitative standardized uptake values (SUV) measurements. Methods One hundred four consecutively scanned patients (51 men and 53 women; mean age, 56.4 years) with confirmed diagnosis of NET underwent PET/CT 1 hour after administration of 68 Ga-DOTA-TATE. SUV mean, and SUV max were measured in 37 normal anatomical structures for each patient. Abnormal uptake was divided into benign, indeterminate, and malignant categories based on imaging characteristic, clinical follow-up, and pathology. Results High physiologic uptake (SUV max > 7) was observed in spleen, renal parenchyma, adrenal glands, pituitary gland, stomach, and liver (in decreasing order). Moderate uptake (3.5-7) was present in the prostate, jejunum, pancreas, ileum, and salivary glands. Mild uptake (2-3.5) was present in the uterus, colon, thyroid, rectum, and skeleton. A total of 678 lesions (limited to 5 lesions with highest uptake per organ) were included in the analysis, including 127 benign and 54 indeterminate lesions. Uptake was significantly higher in malignant lesions than in benign lesions, but an overlap was noted between the groups. Conclusions 68 Ga-DOTA TATE uptake in normal and abnormal structures is highly variable in patients with NET. SUV is a useful measure for characterizing benign versus malignant lesions. Anatomical and clinical correlation may be necessary to characterize foci of intermediate uptake.
KW - 68 Ga
KW - DOTA-TATE
KW - PET/CT
KW - neuroendocrine tumors
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U2 - 10.1097/RLU.0000000000001100
DO - 10.1097/RLU.0000000000001100
M3 - Article
C2 - 26673240
AN - SCOPUS:84950147895
SN - 0363-9762
VL - 41
SP - e281-e287
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
IS - 6
ER -