Spheroidal degeneration of cornea and conjunctiva. 3. Incidences, classification, and etiology

Frederick T. Fraunfelder, Calvin Hanna

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12 Scopus citations


Spheroidal degeneration, an extracellular protein deposit in the cornea and conjunctiva, has been found in three basic patterns in the southwestern portion of the United States: (1) the primary corneal form which is seen in the horizontal meridian adjacent to the limbus; (2) secondary corneal form found anywhere in the cornea and in geographic areas free of environmental extremes usually associated with significant corneal pathology; and (3) a conjunctival form which is frequently associated with pinguecula. One of the three forms of spheroidal degeneration was found in over 40% of patients over the age of 50 years, and was seen three times more frequently in males than females; also, the corneal forms were more frequently associated with glaucoma. Although many factors may be important in the etiology of this entity, normal aging changes and sun rays probably play a major role.

Original languageEnglish (US)
Pages (from-to)41-50
Number of pages10
JournalAmerican journal of ophthalmology
Issue number1
StatePublished - Jul 1973
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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