TY - JOUR
T1 - Splanchnic, thoracoabdominal, and cerebral blood flow volumes in healthy children and young adults in fasting and postprandial states
T2 - Determining reference ranges by using phase-contrast MR Imaging
AU - Muthusami, Prakash
AU - Yoo, Shi Joon
AU - Chaturvedi, Rajiv
AU - Gill, Navjot
AU - Windram, Jonathan
AU - Schantz, Daryl
AU - Prsa, Milan
AU - Caro-Dominguez, Pablo
AU - Seed, Mike
AU - Grosse-Wortmann, Lars
AU - Ling, Simon C.
AU - Chavhan, Govind B.
N1 - Publisher Copyright:
© RSNA, 2017.
PY - 2017/10
Y1 - 2017/10
N2 - Purpose: To estimate reference ranges for blood flow volume (BFV) in major splanchnic, thoracoabdominal, and neck vessels by using phase-contrast magnetic resonance (MR) imaging in children and young adults in fasting and postprandial states. Materials and Methods: In this institutional research ethics board-approved prospective study, healthy volunteers underwent phasecontrast MR imaging in a fasting state and again after a standardized meal. BFV values were reported as medians and ranges, and postmeal to premeal BFV ratios were calculated. BFVs in volunteers divided into two groups according to age (≤18 years old and >18 years old) were compared by using the Mann-Whitney test adjusted for multiple comparisons. Linear regression for internal validation of BFV and Pearson correlation and Bland-Altman analysis for interobserver agreement were used. Results: Reference ranges for BFVs were estimated in 39 volunteers (23 male and 16 female; mean age, 21.2 years ± 8.5; range, 9-40 years) and were indexed according to body surface area, with internal validation (R2 = 0.84-0.92) and excellent interobserver agreement (R2 = 0.9928). There was an almost 30% increase in total abdominal BFV (P < .0001) in response to a meal, which was the result of a threefold increase in superior mesenteric artery BFV (P <.0001). BFV after the meal remained unaffected in the celiac artery and cerebral circulation. Significantly higher normalized BFVs in the cerebral circulation were measured in children with both preprandial (P = .039) and postprandial (P = .008) status than those in adults. Conclusion: Reference ranges for BFVs and changes in BFVs in response to a meal in major splanchnic, thoracoabdominal, and neck vessels were estimated by using phase-contrast MR imaging in healthy volunteers to allow hemodynamic assessment of children and young adults with various diseases.
AB - Purpose: To estimate reference ranges for blood flow volume (BFV) in major splanchnic, thoracoabdominal, and neck vessels by using phase-contrast magnetic resonance (MR) imaging in children and young adults in fasting and postprandial states. Materials and Methods: In this institutional research ethics board-approved prospective study, healthy volunteers underwent phasecontrast MR imaging in a fasting state and again after a standardized meal. BFV values were reported as medians and ranges, and postmeal to premeal BFV ratios were calculated. BFVs in volunteers divided into two groups according to age (≤18 years old and >18 years old) were compared by using the Mann-Whitney test adjusted for multiple comparisons. Linear regression for internal validation of BFV and Pearson correlation and Bland-Altman analysis for interobserver agreement were used. Results: Reference ranges for BFVs were estimated in 39 volunteers (23 male and 16 female; mean age, 21.2 years ± 8.5; range, 9-40 years) and were indexed according to body surface area, with internal validation (R2 = 0.84-0.92) and excellent interobserver agreement (R2 = 0.9928). There was an almost 30% increase in total abdominal BFV (P < .0001) in response to a meal, which was the result of a threefold increase in superior mesenteric artery BFV (P <.0001). BFV after the meal remained unaffected in the celiac artery and cerebral circulation. Significantly higher normalized BFVs in the cerebral circulation were measured in children with both preprandial (P = .039) and postprandial (P = .008) status than those in adults. Conclusion: Reference ranges for BFVs and changes in BFVs in response to a meal in major splanchnic, thoracoabdominal, and neck vessels were estimated by using phase-contrast MR imaging in healthy volunteers to allow hemodynamic assessment of children and young adults with various diseases.
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U2 - 10.1148/radiol.2017162114
DO - 10.1148/radiol.2017162114
M3 - Article
C2 - 28530848
AN - SCOPUS:85029683111
SN - 0033-8419
VL - 285
SP - 231
EP - 241
JO - Radiology
JF - Radiology
IS - 1
ER -