Spontaneous inhibitory synaptic currents mediated by a g protein-coupled receptor

Stephanie C. Gantz; James R. Bunzow; John T. Williams

doi:10.1016/j.neuron.2013.04.013

Spontaneous inhibitory synaptic currents mediated by a g protein-coupled receptor

Stephanie C. Gantz, James R. Bunzow, John T. Williams

Vollum Institute

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

G protein-coupled receptors (GPCRs) affect many physiological processes by modulating both intrinsic membrane conductances and synaptic transmission. This study describes spontaneous miniature inhibitory postsynaptic currents mediated by vesicular dopamine release acting locally on metabotropic D₂ receptors leading to the activation of a G protein-coupled inwardly rectifying potassium conductance. Thus, individual exocytotic events result in spontaneous GPCR-mediated transmission, similar to synaptic activation of classical ligand-gated ion channels

Original language	English (US)
Pages (from-to)	807-812
Number of pages	6
Journal	Neuron
Volume	78
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2013.04.013
State	Published - Jun 5 2013

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2013.04.013

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title = "Spontaneous inhibitory synaptic currents mediated by a g protein-coupled receptor",

abstract = "G protein-coupled receptors (GPCRs) affect many physiological processes by modulating both intrinsic membrane conductances and synaptic transmission. This study describes spontaneous miniature inhibitory postsynaptic currents mediated by vesicular dopamine release acting locally on metabotropic D2 receptors leading to the activation of a G protein-coupled inwardly rectifying potassium conductance. Thus, individual exocytotic events result in spontaneous GPCR-mediated transmission, similar to synaptic activation of classical ligand-gated ion channels",

author = "Gantz, {Stephanie C.} and Bunzow, {James R.} and Williams, {John T.}",

note = "Funding Information: We thank Dr. C.P. Ford for comments on the work and manuscript. Supported by NIH DA04523.",

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AU - Gantz, Stephanie C.

AU - Bunzow, James R.

AU - Williams, John T.

N1 - Funding Information: We thank Dr. C.P. Ford for comments on the work and manuscript. Supported by NIH DA04523.

PY - 2013/6/5

Y1 - 2013/6/5

N2 - G protein-coupled receptors (GPCRs) affect many physiological processes by modulating both intrinsic membrane conductances and synaptic transmission. This study describes spontaneous miniature inhibitory postsynaptic currents mediated by vesicular dopamine release acting locally on metabotropic D2 receptors leading to the activation of a G protein-coupled inwardly rectifying potassium conductance. Thus, individual exocytotic events result in spontaneous GPCR-mediated transmission, similar to synaptic activation of classical ligand-gated ion channels

AB - G protein-coupled receptors (GPCRs) affect many physiological processes by modulating both intrinsic membrane conductances and synaptic transmission. This study describes spontaneous miniature inhibitory postsynaptic currents mediated by vesicular dopamine release acting locally on metabotropic D2 receptors leading to the activation of a G protein-coupled inwardly rectifying potassium conductance. Thus, individual exocytotic events result in spontaneous GPCR-mediated transmission, similar to synaptic activation of classical ligand-gated ion channels

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JO - Neuron

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Spontaneous inhibitory synaptic currents mediated by a g protein-coupled receptor

Abstract

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