TY - JOUR
T1 - STI prevalence, incidence, and partner notification among women in a periconception HIV prevention program in Uganda
AU - Chitneni, Pooja
AU - Muyindike, Winnie
AU - Bwana, Mwebesa Bosco
AU - Owembabazi, Moran
AU - O’Neil, Kasey
AU - Kalyebara, Paul Kato
AU - Hedt-Gauthier, Bethany
AU - Bangsberg, David R.
AU - Marrazzo, Jeanne M.
AU - Kaida, Angela
AU - Haberer, Jessica E.
AU - Matthews, Lynn T.
N1 - Funding Information:
We would like to thank our participants for their contributions to this study. We would also like to thank several colleagues including, Deogratious Tukwasibwe, Alice Najjuma, JohnMary Tumwine, Catherine Kyampire, Sylvia Natukynda, Adolf Byamukama, Yona Mbalibulha. This study is funded through the Doris Duke Charitable Foundation. PC received funding from the National Institute of Allergy and Infectious Diseases under award number T32 AI007433, and from the Fogarty International Center and National Institute of Mental Health under award number D43 TW010543 all under the National Institutes of Health. JEH is supported by K24MH114732. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Funding Information:
This study is funded through the Doris Duke Charitable Foundation. PC received funding from the National Institute of Allergy and Infectious Diseases under award number T32 AI007433, and from the Fogarty International Center and National Institute of Mental Health under award number D43 TW010543 all under the National Institutes of Health. JEH is supported by K24MH114732. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© The Author(s) 2022.
PY - 2022/8
Y1 - 2022/8
N2 - Background: We provided sexually transmitted infection (STI) screening and facilitated partner notification and treatment among women participating in a periconception HIV prevention program in southwestern Uganda to understand follow-up STI incidence. Methods: Women at-risk for HIV exposure while planning for pregnancy completed laboratory screening for chlamydia, gonorrhea, trichomoniasis, and syphilis at enrollment and 6 months of follow-up and/or incident pregnancy; facilitated partner notification and treatment were offered for those with positive tests. We performed a logistic regression to determine correlates of follow-up STI. Results: Ninety-four participants completed enrollment STI screening with a median age of 29 (IQR 26–34); 23 (24%) had ≥1 STI. Of the 23 participants with enrollment STI(s), all completed treatment and 19 (83%) returned for follow-up; 18 (78%) reported delivering partner notification cards and discussing STIs with partner(s), and 14 (61%) reported all partners received STI treatment. Of the 81 (86%) who successfully completed follow-up STI screening, 17 (21%) had ≥1 STI. The STI incidence rate was 29.0 per 100 person-years. In univariable regression analysis, enrollment STI, younger age, less education, and alcohol consumption were all significantly associated with follow-up STI. Conclusions: We demonstrated high enrollment and follow-up STI rates and moderate participant-reported partner treatment among women planning for pregnancy in Uganda despite partner notification and treatment. Novel STI partner notification and treatment interventions are needed to decrease the STI burden, especially among women planning for and with pregnancy.
AB - Background: We provided sexually transmitted infection (STI) screening and facilitated partner notification and treatment among women participating in a periconception HIV prevention program in southwestern Uganda to understand follow-up STI incidence. Methods: Women at-risk for HIV exposure while planning for pregnancy completed laboratory screening for chlamydia, gonorrhea, trichomoniasis, and syphilis at enrollment and 6 months of follow-up and/or incident pregnancy; facilitated partner notification and treatment were offered for those with positive tests. We performed a logistic regression to determine correlates of follow-up STI. Results: Ninety-four participants completed enrollment STI screening with a median age of 29 (IQR 26–34); 23 (24%) had ≥1 STI. Of the 23 participants with enrollment STI(s), all completed treatment and 19 (83%) returned for follow-up; 18 (78%) reported delivering partner notification cards and discussing STIs with partner(s), and 14 (61%) reported all partners received STI treatment. Of the 81 (86%) who successfully completed follow-up STI screening, 17 (21%) had ≥1 STI. The STI incidence rate was 29.0 per 100 person-years. In univariable regression analysis, enrollment STI, younger age, less education, and alcohol consumption were all significantly associated with follow-up STI. Conclusions: We demonstrated high enrollment and follow-up STI rates and moderate participant-reported partner treatment among women planning for pregnancy in Uganda despite partner notification and treatment. Novel STI partner notification and treatment interventions are needed to decrease the STI burden, especially among women planning for and with pregnancy.
KW - Africa
KW - chlamydia (Chlamydia trachomatis)
KW - epidemiology
KW - gonorrhea (Neisseria gonorrhoeae)
KW - syphilis (Treponema pallidum)
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U2 - 10.1177/09564624221110992
DO - 10.1177/09564624221110992
M3 - Article
C2 - 35775125
AN - SCOPUS:85133307429
SN - 0956-4624
VL - 33
SP - 856
EP - 863
JO - International Journal of STD and AIDS
JF - International Journal of STD and AIDS
IS - 9
ER -