TY - JOUR
T1 - Strain differences in behavioral inhibition in a go/No-go task demonstrated using 15 inbred mouse strains
AU - Gubner, Noah R.
AU - Wilhelm, Clare J.
AU - Phillips, Tamara J.
AU - Mitchell, Suzanne H.
N1 - Funding Information:
This work was supported by grants from Instituto de Salud Carlos III (PI06/0155, FIS2009/01636), Fundación Investigación Médica Mutua Madrileña (2008/93, 2010/ 0004) and CIBERNED (BESAD-P.2010). We thank Agnieszka Krzyzanowska, PhD, for the careful revision of this manuscript.
PY - 2010/8
Y1 - 2010/8
N2 - Background: High levels of impulsivity have been associated with a number of substance abuse disorders including alcohol abuse. Research has not yet revealed whether these high levels predate the development of alcohol abuse. Methods: The current study examined impulsivity in 15 inbred strains of mice (A/HeJ, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6J, C57L/J, C58/J, CBA/J, DBA/1J, DBA/2J, NZB/B1NJ, PL/J, SJL/J, SWR/J, and 129P3/J) using a Go/No-go task, which was designed to measure a subject's ability to inhibit a behavior. Numerous aspects of response to ethanol and other drugs of abuse have been examined in these strains. Results: There were significant strain differences in the number of responses made during the No-go signal (false alarms) and the extent to which strains responded differentially during the Go and No-go signals (d'). The rate of responding prior to the cue did not differ among strains, although there was a statistically significant correlation between false alarms and precue responding that was not related to basal activity level. Interstrain correlations suggested that false alarms and rate of responding were associated with strain differences in ethanol-related traits from the published literature. Conclusions: The results of this study do support a link between innate level of impulsivity and response to ethanol and are consistent with a genetic basis for some measures of behavioral inhibition.
AB - Background: High levels of impulsivity have been associated with a number of substance abuse disorders including alcohol abuse. Research has not yet revealed whether these high levels predate the development of alcohol abuse. Methods: The current study examined impulsivity in 15 inbred strains of mice (A/HeJ, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6J, C57L/J, C58/J, CBA/J, DBA/1J, DBA/2J, NZB/B1NJ, PL/J, SJL/J, SWR/J, and 129P3/J) using a Go/No-go task, which was designed to measure a subject's ability to inhibit a behavior. Numerous aspects of response to ethanol and other drugs of abuse have been examined in these strains. Results: There were significant strain differences in the number of responses made during the No-go signal (false alarms) and the extent to which strains responded differentially during the Go and No-go signals (d'). The rate of responding prior to the cue did not differ among strains, although there was a statistically significant correlation between false alarms and precue responding that was not related to basal activity level. Interstrain correlations suggested that false alarms and rate of responding were associated with strain differences in ethanol-related traits from the published literature. Conclusions: The results of this study do support a link between innate level of impulsivity and response to ethanol and are consistent with a genetic basis for some measures of behavioral inhibition.
KW - Ethanol
KW - Go/No-go
KW - Heritability
KW - Impulsivity
KW - Inbred Strains
KW - Inhibition
KW - Locomotion
KW - Mice
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U2 - 10.1111/j.1530-0277.2010.01219.x
DO - 10.1111/j.1530-0277.2010.01219.x
M3 - Article
C2 - 20491731
AN - SCOPUS:77954893234
SN - 0145-6008
VL - 34
SP - 1353
EP - 1362
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
IS - 8
ER -