Structure-activity relationships of flavonoids

Vaya Jacob, Tavori Hagai, Khatib Soliman

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Flavonoids are secondary metabolites produced in plants that have diverse biological activities. The present review summarizesinformation gathered mostly in the last six years on the flavonoids' structure-activity relationships, specifically with respect to: A)phytoestrogenic activity-flavonoids' potential to replace estrogen during the menopausal period and especially fascinating, the possibilityof finding flavonoids selective for estrogen receptor β B) as antioxidants-their potential to treat oxidative stress-associated diseases; C)as whitening agents-potentially active via their ability to inhibit the enzyme tyrosinase; D) flavonoids that are active due to their interactionwith proteins (enzymes, receptors, transporters and transcription factors), an area which we believe will attract much more attentionin the near future, in helping to understand the role of flavonoids and their mechanism of action in the treatment of human diseases. Thisreview covers data collected from experiments performed using flavonoids with known structure rather than crude extracts, and in thefirst two sections (A and B), the focus is on results obtained from in-vivo experiments, where available.

Original languageEnglish (US)
Pages (from-to)2641-2657
Number of pages17
JournalCurrent Organic Chemistry
Issue number15
StatePublished - 2011
Externally publishedYes


  • Antioxidants
  • Flavonoids
  • Phytoestrogen
  • Protein interaction
  • Whitening agent

ASJC Scopus subject areas

  • Organic Chemistry


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