TY - JOUR
T1 - Structure of the Human Vasoactive Intestinal Polypeptide Gene
AU - Tsukada, Toshihiko
AU - Horovitch, Sharon J.
AU - Montminy, Marc R.
AU - Mandel, Gail
AU - Goodman, Richard H.
PY - 1985/8
Y1 - 1985/8
N2 - Vasoactive intestinal polypeptide (VIP) is a 28-amino-acid hormone produced primarily by neural tissues. The amino acid sequence of VIP is similar to that of a number of gastrointestinal hormones, including glucagon and secretin. VIP is synthesized as part of a polyprotein, pre-proVIP, which generates, in addition to VIP, an additional bioactive peptide known as PHM. As a first step toward understanding the molecular basis of pre-proVIP gene expression, we have isolated the pre-proVIP gene and have determined its structure. The gene is approximately 9 kb long and is interrupted by six introns which appear to divide the gene into functional domains. One of the introns occurs within the 3′-untranslated region of the gene.
AB - Vasoactive intestinal polypeptide (VIP) is a 28-amino-acid hormone produced primarily by neural tissues. The amino acid sequence of VIP is similar to that of a number of gastrointestinal hormones, including glucagon and secretin. VIP is synthesized as part of a polyprotein, pre-proVIP, which generates, in addition to VIP, an additional bioactive peptide known as PHM. As a first step toward understanding the molecular basis of pre-proVIP gene expression, we have isolated the pre-proVIP gene and have determined its structure. The gene is approximately 9 kb long and is interrupted by six introns which appear to divide the gene into functional domains. One of the introns occurs within the 3′-untranslated region of the gene.
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U2 - 10.1089/dna.1985.4.293
DO - 10.1089/dna.1985.4.293
M3 - Article
C2 - 3899557
AN - SCOPUS:0022413142
SN - 0198-0238
VL - 4
SP - 293
EP - 300
JO - DNA
JF - DNA
IS - 4
ER -