Studies using macaque monkeys to address excessive alcohol drinking and stress interactions

Vanessa A. Jimenez, Kathleen A. Grant

    Research output: Contribution to journalReview articlepeer-review

    24 Scopus citations


    The use of non-human primates (NHPs) in studies of volitional, oral self-administration of alcohol can help address the complex interplay between stress and excessive alcohol consumption. There are aspects to brain, endocrine and behavior of NHPs, particularly macaques, that provide a critical translational link towards understanding the risks and consequences of alcohol use disorders (AUDs) in humans. These include wide individual differences in escalating daily alcohol intake, accurate measures of hypothalamic-pituitary-adrenal (HPA) axis hormonal interactions, neuroanatomical specificity of synaptic adaptations to chronic alcohol, genetic similarities to humans, and the ability to conduct in vivo brain imaging. When placed in a framework that alcohol addiction is a sequence of dysregulations in motivational circuitry associated with severity of AUD, the NHP can provide within-subject information on both risks for and consequences of repeatedly drinking to intoxication. Notably, long-term adaptations in neurocircuitry that mediate behavioral reinforcement, stress responses and executive functions are possible with NHPs. We review here the substantial progress made using NHPs to address the complex relationship between alcohol and stress as risk factors and consequences of daily drinking to intoxication. This review also highlights areas where future studies of brain and HPA axis adaptations are needed to better understand the mechanisms involved in stress leading to excessive alcohol consumption. This article is part of the Special Issue entitled “Alcoholism”.

    Original languageEnglish (US)
    Pages (from-to)127-135
    Number of pages9
    StatePublished - Aug 1 2017


    • Alcohol
    • Allostasis
    • Ethanol
    • Monkey
    • Self-administration
    • Stress

    ASJC Scopus subject areas

    • Pharmacology
    • Cellular and Molecular Neuroscience


    Dive into the research topics of 'Studies using macaque monkeys to address excessive alcohol drinking and stress interactions'. Together they form a unique fingerprint.

    Cite this