TY - JOUR
T1 - Sultam thiourea inhibition of West Nile virus
AU - Barklis, Eric
AU - Still, Amelia
AU - Sabri, Mohammad I.
AU - Hirsch, Alec J.
AU - Nikolich-Zugich, Janko
AU - Brien, James
AU - Dhenub, Tenzin Choesang
AU - Scholz, Isabel
AU - Alfadhli, Ayna
PY - 2007/7
Y1 - 2007/7
N2 - We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.
AB - We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.
UR - http://www.scopus.com/inward/record.url?scp=34447271709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447271709&partnerID=8YFLogxK
U2 - 10.1128/AAC.00007-07
DO - 10.1128/AAC.00007-07
M3 - Article
C2 - 17452483
AN - SCOPUS:34447271709
SN - 0066-4804
VL - 51
SP - 2642
EP - 2645
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 7
ER -