Suppression of food intake by glp1r/lepr-coexpressing neurons prevents obesity in mouse models

Alan C. Rupp; Abigail J. Tomlinson; Alison H. Affinati; Warren T. Yacawych; Allison M. Duensing; Cadence True; Sarah R. Lindsley; Melissa A. Kirigiti; Alexander Mackenzie; Joseph Polex-Wolf; Chien Li; Lotte Bjerre Knudsen; Randy J. Seeley; David P. Olson; Paul Kievit; Martin G. Myers

doi:10.1172/JCI157515

Suppression of food intake by glp1r/lepr-coexpressing neurons prevents obesity in mouse models

Alan C. Rupp, Abigail J. Tomlinson, Alison H. Affinati, Warren T. Yacawych, Allison M. Duensing, Cadence True, Sarah R. Lindsley, Melissa A. Kirigiti, Alexander Mackenzie, Joseph Polex-Wolf, Chien Li, Lotte Bjerre Knudsen, Randy J. Seeley, David P. Olson, Paul Kievit, Martin G. Myers

Oregon National Primate Research Center

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We thank members of the Myers and Olson labs for helpful discussions and Qing Zhu from the Molecular Genetics Core for mouse line production. We thank Steve Liberles (Harvard Medical School) for sharing Glp1r^Cre and Joel Elmquist (University of Texas Southwestern) and Streamson Chua (Albert Einstein College of Medicine) for sharing the Lepr^LSL and Lepr^FSF-fl alleles. We thank Carey Lumeng and members of his lab for insights into sorting nuclei for snRNA-Seq. Research support was provided by NIH DK056731 (to MGM) and the Michigan Diabetes Research Center (NIH P30 DK020572, including the Molecular Genetics, Microscopy and image analysis core, and Animal Studies Cores), the Marilyn H. Vincent Foundation (to MGM), and Novo Nordisk (to MGM). ACR was supported in part by NIDDK DKNet award KR704666 under 5 U24 DK097771.

Original language	English (US)
Article number	e157515
Journal	Journal of Clinical Investigation
Volume	133
Issue number	19
DOIs	https://doi.org/10.1172/JCI157515
State	Published - Aug 15 2023

ASJC Scopus subject areas

General Medicine

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10.1172/JCI157515

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Rupp, A. C., Tomlinson, A. J., Affinati, A. H., Yacawych, W. T., Duensing, A. M., True, C., Lindsley, S. R., Kirigiti, M. A., Mackenzie, A., Polex-Wolf, J., Li, C., Knudsen, L. B., Seeley, R. J., Olson, D. P., Kievit, P., & Myers, M. G. (2023). Suppression of food intake by glp1r/lepr-coexpressing neurons prevents obesity in mouse models. Journal of Clinical Investigation, 133(19), Article e157515. https://doi.org/10.1172/JCI157515

Rupp, AC, Tomlinson, AJ, Affinati, AH, Yacawych, WT, Duensing, AM, True, C, Lindsley, SR, Kirigiti, MA, Mackenzie, A, Polex-Wolf, J, Li, C, Knudsen, LB, Seeley, RJ, Olson, DP, Kievit, P & Myers, MG 2023, 'Suppression of food intake by glp1r/lepr-coexpressing neurons prevents obesity in mouse models', Journal of Clinical Investigation, vol. 133, no. 19, e157515. https://doi.org/10.1172/JCI157515

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title = "Suppression of food intake by glp1r/lepr-coexpressing neurons prevents obesity in mouse models",

abstract = "We thank members of the Myers and Olson labs for helpful discussions and Qing Zhu from the Molecular Genetics Core for mouse line production. We thank Steve Liberles (Harvard Medical School) for sharing Glp1rCre and Joel Elmquist (University of Texas Southwestern) and Streamson Chua (Albert Einstein College of Medicine) for sharing the LeprLSL and LeprFSF-fl alleles. We thank Carey Lumeng and members of his lab for insights into sorting nuclei for snRNA-Seq. Research support was provided by NIH DK056731 (to MGM) and the Michigan Diabetes Research Center (NIH P30 DK020572, including the Molecular Genetics, Microscopy and image analysis core, and Animal Studies Cores), the Marilyn H. Vincent Foundation (to MGM), and Novo Nordisk (to MGM). ACR was supported in part by NIDDK DKNet award KR704666 under 5 U24 DK097771.",

author = "Rupp, {Alan C.} and Tomlinson, {Abigail J.} and Affinati, {Alison H.} and Yacawych, {Warren T.} and Duensing, {Allison M.} and Cadence True and Lindsley, {Sarah R.} and Kirigiti, {Melissa A.} and Alexander Mackenzie and Joseph Polex-Wolf and Chien Li and Knudsen, {Lotte Bjerre} and Seeley, {Randy J.} and Olson, {David P.} and Paul Kievit and Myers, {Martin G.}",

note = "Publisher Copyright: {\textcopyright} 2023, Rupp et al.",

year = "2023",

month = aug,

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doi = "10.1172/JCI157515",

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AU - Tomlinson, Abigail J.

AU - Affinati, Alison H.

AU - Yacawych, Warren T.

AU - Duensing, Allison M.

AU - True, Cadence

AU - Lindsley, Sarah R.

AU - Kirigiti, Melissa A.

AU - Mackenzie, Alexander

AU - Polex-Wolf, Joseph

AU - Li, Chien

AU - Knudsen, Lotte Bjerre

AU - Seeley, Randy J.

AU - Olson, David P.

AU - Kievit, Paul

AU - Myers, Martin G.

PY - 2023/8/15

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N2 - We thank members of the Myers and Olson labs for helpful discussions and Qing Zhu from the Molecular Genetics Core for mouse line production. We thank Steve Liberles (Harvard Medical School) for sharing Glp1rCre and Joel Elmquist (University of Texas Southwestern) and Streamson Chua (Albert Einstein College of Medicine) for sharing the LeprLSL and LeprFSF-fl alleles. We thank Carey Lumeng and members of his lab for insights into sorting nuclei for snRNA-Seq. Research support was provided by NIH DK056731 (to MGM) and the Michigan Diabetes Research Center (NIH P30 DK020572, including the Molecular Genetics, Microscopy and image analysis core, and Animal Studies Cores), the Marilyn H. Vincent Foundation (to MGM), and Novo Nordisk (to MGM). ACR was supported in part by NIDDK DKNet award KR704666 under 5 U24 DK097771.

AB - We thank members of the Myers and Olson labs for helpful discussions and Qing Zhu from the Molecular Genetics Core for mouse line production. We thank Steve Liberles (Harvard Medical School) for sharing Glp1rCre and Joel Elmquist (University of Texas Southwestern) and Streamson Chua (Albert Einstein College of Medicine) for sharing the LeprLSL and LeprFSF-fl alleles. We thank Carey Lumeng and members of his lab for insights into sorting nuclei for snRNA-Seq. Research support was provided by NIH DK056731 (to MGM) and the Michigan Diabetes Research Center (NIH P30 DK020572, including the Molecular Genetics, Microscopy and image analysis core, and Animal Studies Cores), the Marilyn H. Vincent Foundation (to MGM), and Novo Nordisk (to MGM). ACR was supported in part by NIDDK DKNet award KR704666 under 5 U24 DK097771.

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Suppression of food intake by glp1r/lepr-coexpressing neurons prevents obesity in mouse models

Abstract

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