Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors: A comparative review of 22 articles

Joost J. Nuyttens, Philip F. Rust, Charles R. Thomas, Andrew T. Turrisi

Research output: Contribution to journalReview articlepeer-review

438 Scopus citations


BACKGROUND. Desmoid tumors (aggressive fibromatoses) are benign neoplasms with high rates of recurrence after surgery. Radiotherapy is sometimes reported to prevent recurrences, but not in all studies. In order to evaluate the effect of radiation, comparative analysis was performed. METHODS. The authors conducted a MEDLINE search and collected all articles in the English language on the treatment of 'desmoid tumor' or 'aggressive fibromatosis' from the years 1983-1998. They categorized treatment into three groups: surgery, alone (S), surgery with radiotherapy (S + RT), or radiotherapy alone (RT). The S and S + RT groups were each subdivided according to whether margins were free (-), positive (+), or unknown. Each subgroup was divided into cases with primary, recurrent, or unknown tumor. RESULTS. The local control rates after treatment for cases in the S group with (-) margins, (+) margins, and overall were 72%, 41%, and 61%, respectively. For the S + RT group the local control results were 94%, 75%, and 75%, respectively, significantly different when compared with the results for the S group. For the RT group, the local control was 78%, significantly superior to that of the S group (61%). Cases with primary and recurrent tumors had significantly superior local control rates with S + RT or RT versus S. Radiotherapy complications noted were fibrosis, paresthesias, edema, and fracture. CONCLUSIONS. RT or S + RT results in significantly better local control than S. Even after dividing the groups into cases with free and positive margins and cases with primary and recurrent tumors, the best local control is achieved with RT or S + RT. (C) 2000 American Cancer Society.

Original languageEnglish (US)
Pages (from-to)1517-1523
Number of pages7
Issue number7
StatePublished - Apr 1 2000
Externally publishedYes


  • Aggressive fibromatosis
  • Complications
  • Desmoid tumor
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors: A comparative review of 22 articles'. Together they form a unique fingerprint.

Cite this