@article{337eda77cb014017a603034d78c02241,
title = "Survival advantage of coagulation factor XI-deficient mice during peritoneal sepsis",
abstract = "Anticoagulation is a rational approach to the treatment of sepsis-associated consumptive coagulopathy, but its application is limited because of the risk of excessive bleeding. Factor XI (FXI) contributes substantially to pathological blood coagulation (thrombosis), whereas it contributes only modestly to normal hemostasis. We found that FXI-deficient mice have reduced coagulopathy and increased survival relative to FXI-expressing wild-type mice during cecal ligation and puncture-induced acute peritonitis/sepsis. This finding suggests that FXI contributes to coagulopathy and/or inflammation during sepsis and that pharmacologic inhibition of FXI activity may alter the course and outcome of some infections.",
author = "Tucker, {Erik I.} and David Gailani and Sawan Hurst and Qiufang Cheng and Hanson, {Stephen R.} and Andr{\'a}s Gruber",
note = "Funding Information: Received 1 August 2007; accepted 4 February 2008; electronically published 19 May 2008. Potential conflicts of interest: none reported. Presented in part: 44th Annual Meeting of the Infectious Diseases Society of America, Toronto, 12–15 October 2006 (abstract 341a); 48th Annual Meeting of the American Society of Hematology, Orlando, 9–12 December 2006 (abstract 1005a); XXIst Congress of the International Society on Thrombosis and Haemostasis, Geneva, 7–12 July 2007 (abstract P-W-011). Financial support: National Heart, Lung, and Blood Institute (grants HL58837 and HL81326 to D.G.). Reprints or correspondence: Dr. Andr{\'a}s Gruber, Dept. of Biomedical Engineering, Oregon Health and Science University, 3303 SW Bond Ave., CH13B, Portland, Oregon 97239 (grubera@ohsu.edu).",
year = "2008",
month = jul,
day = "15",
doi = "10.1086/589514",
language = "English (US)",
volume = "198",
pages = "271--274",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",
}