TY - JOUR
T1 - Synbiotics and Surgery
T2 - Can Prebiotics and Probiotics Affect Inflammatory Surgical Outcomes?
AU - Trone, Kristin
AU - Rahman, Shahrose
AU - Green, Caitlin Homberger
AU - Venegas, Carla
AU - Martindale, Robert
AU - Stroud, Andrea
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/6
Y1 - 2023/6
N2 - Purpose of Review: Prebiotics, probiotics, and synbiotics have received increasing attention over the years for their beneficial impact on the gut microbiome and for their systemic anti-inflammatory effects. They have also been shown to improve surgical outcomes. Here, we review the inflammatory effects of surgery as well as the data which suggests a benefit of prebiotics, probiotics, and synbiotics taken in the perioperative period. Recent Findings: Synbiotics and fermented foods may have an even greater anti-inflammatory effect than probiotics or prebiotics alone. Recent data suggest that the anti-inflammatory effects and microbiome changes brought on by prebiotics, probiotics, and synbiotics have the potential to improve surgical outcomes. We highlight the potential to alter systemic inflammation, surgical and hospital-acquired infections, colorectal cancer formation, recurrence, and anastomotic leak. Synbiotics could also impact metabolic syndrome. Summary: Prebiotics, probiotics, and especially synbiotics may be extremely beneficial when taken in the perioperative period. Even short-term gut microbiome pre-habilitation could alter surgical outcomes significantly.
AB - Purpose of Review: Prebiotics, probiotics, and synbiotics have received increasing attention over the years for their beneficial impact on the gut microbiome and for their systemic anti-inflammatory effects. They have also been shown to improve surgical outcomes. Here, we review the inflammatory effects of surgery as well as the data which suggests a benefit of prebiotics, probiotics, and synbiotics taken in the perioperative period. Recent Findings: Synbiotics and fermented foods may have an even greater anti-inflammatory effect than probiotics or prebiotics alone. Recent data suggest that the anti-inflammatory effects and microbiome changes brought on by prebiotics, probiotics, and synbiotics have the potential to improve surgical outcomes. We highlight the potential to alter systemic inflammation, surgical and hospital-acquired infections, colorectal cancer formation, recurrence, and anastomotic leak. Synbiotics could also impact metabolic syndrome. Summary: Prebiotics, probiotics, and especially synbiotics may be extremely beneficial when taken in the perioperative period. Even short-term gut microbiome pre-habilitation could alter surgical outcomes significantly.
KW - Fermented foods
KW - Inflammation
KW - Surgical outcomes
KW - Surgical site infections
KW - Synbiotics
UR - http://www.scopus.com/inward/record.url?scp=85151350626&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85151350626&partnerID=8YFLogxK
U2 - 10.1007/s13668-023-00464-1
DO - 10.1007/s13668-023-00464-1
M3 - Review article
C2 - 36991238
AN - SCOPUS:85151350626
SN - 2161-3311
VL - 12
SP - 238
EP - 246
JO - Current Nutrition Reports
JF - Current Nutrition Reports
IS - 2
ER -