Systemic Delivery and Biodistribution of Cisplatin in Vivo

Yu Hsuan Chu, Martha Sibrian-Vazquez, Jorge O. Escobedo, Amanda R. Phillips, D. Thomas Dickey, Qi Wang, Martina Ralle, Peter S. Steyger, Robert M. Strongin

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Cisplatin is widely used to treat a variety of cancers. However, ototoxicity and nephrotoxicity remain serious side effects of cisplatin-based chemotherapy. In order to inform the study of cisplatin's off-target effects, a new drug-fluorophore conjugate was synthesized that exhibited utility as a tracer to determine the cellular uptake and in vivo distribution of cisplatin. This probe will serve as a useful tool to facilitate investigations into the kinetics and biodistribution of cisplatin and its associated side effects in preclinical models after systemic administration.

Original languageEnglish (US)
Pages (from-to)2677-2682
Number of pages6
JournalMolecular Pharmaceutics
Issue number8
StatePublished - Aug 1 2016


  • Texas Red
  • cisplatin
  • conjugate
  • ototoxicity
  • tracer

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery


Dive into the research topics of 'Systemic Delivery and Biodistribution of Cisplatin in Vivo'. Together they form a unique fingerprint.

Cite this