Targeted complexes of lanthanide(III) ions as therapeutic and diagnostic pharmaceuticals

Mark Woods; Zoltan Kovacs; A. Dean Sherry

doi:10.1016/S1472-7862(02)00072-2

Targeted complexes of lanthanide(III) ions as therapeutic and diagnostic pharmaceuticals

Mark Woods, Zoltan Kovacs, A. Dean Sherry

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

The physical, magnetic and nuclear properties of the lanthanide ions have rendered them ideal for use in both diagnostic and therapeutic pharmaceuticals. Recent innovations in biotechnology have opened new possibilities for the design of such pharmaceuticals. By conjugating a suitable targeting vector to the metal chelate it may be possible to target tissue type, cell type, individual proteins and even specific nucleic acid sequences. This review describes recent advances in the targeting of these complexes and discusses their potential in the development of new inorganic pharmaceuticals.

Original language	English (US)
Pages (from-to)	1-15
Number of pages	15
Journal	Journal of Supramolecular Chemistry
Volume	2
Issue number	1-3
DOIs	https://doi.org/10.1016/S1472-7862(02)00072-2
State	Published - Jan 2002
Externally published	Yes

Keywords

Bifunctional chelators
Lanthanides
MRI contrast agents
Radiopharmaceuticals

ASJC Scopus subject areas

Chemistry(all)
Organic Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/S1472-7862(02)00072-2

Cite this

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abstract = "The physical, magnetic and nuclear properties of the lanthanide ions have rendered them ideal for use in both diagnostic and therapeutic pharmaceuticals. Recent innovations in biotechnology have opened new possibilities for the design of such pharmaceuticals. By conjugating a suitable targeting vector to the metal chelate it may be possible to target tissue type, cell type, individual proteins and even specific nucleic acid sequences. This review describes recent advances in the targeting of these complexes and discusses their potential in the development of new inorganic pharmaceuticals.",

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AB - The physical, magnetic and nuclear properties of the lanthanide ions have rendered them ideal for use in both diagnostic and therapeutic pharmaceuticals. Recent innovations in biotechnology have opened new possibilities for the design of such pharmaceuticals. By conjugating a suitable targeting vector to the metal chelate it may be possible to target tissue type, cell type, individual proteins and even specific nucleic acid sequences. This review describes recent advances in the targeting of these complexes and discusses their potential in the development of new inorganic pharmaceuticals.

KW - Bifunctional chelators

KW - Lanthanides

KW - MRI contrast agents

KW - Radiopharmaceuticals

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Targeted complexes of lanthanide(III) ions as therapeutic and diagnostic pharmaceuticals

Abstract

Keywords

ASJC Scopus subject areas

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