Targeting brain tissue oxygenation in traumatic brain injury

Ross P. Martini, Steven Deem, Miriam M. Treggiari

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The management of patients with traumatic brain injury has evolved in the last several years, due to the introduction of new, invasive monitoring devices. The ability to monitor parameters other than measurements related to pressures has generated substantial interest. Brain tissue oxygenation monitoring has been consistently shown to provide prognostic information, as indicated by poor prognosis associated with low brain tissue oxygen values. Furthermore, various physiologic manipulations, including increasing the PaO2, have been associated with an increase in brain tissue oxygenation. Whether brain-oxygenation-guided therapy results in improvement in outcomes is debatable. Retrospective studies suggest benefit, while prospective studies have shown a higher intensity of therapeutic interventions with no outcome differences. Data from high quality randomized trials are necessary to determine if brain-oxygenation-guided therapy is beneficial. An oxygen challenge (transient increase in FIO2 to 0.6 up to 1.0) to assess the responsiveness of the monitoring and ascertain the presence of technical malfunction is an accepted practice.

Original languageEnglish (US)
Pages (from-to)162-169
Number of pages8
JournalRespiratory care
Issue number1
StatePublished - Jan 1 2013
Externally publishedYes


  • Brain
  • Brain injury
  • Oxygen
  • Oxygenation
  • Trauma

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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