TY - JOUR
T1 - Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use
AU - Trucco, Elisa M.
AU - Hicks, Brian M.
AU - Villafuerte, Sandra
AU - Nigg, Joel T.
AU - Burmeister, Margit
AU - Zucker, Robert A.
N1 - Funding Information:
Annual Meeting in June, 2015. All authors declare no conflict of interest. This research was supported in part by grants from the National Institute on Alcohol Abuse and Alcoholism (K08 AA023290, R01 AA007065, R01 AA012217, T32 AA07477), the National Institute on Drug Abuse (R01 DA027261, T32 DA07267), and pilot funding from the Michigan Institute for Clinical & Health Research (UL1TR000433). We thank families involved in the Michigan Longitudinal Study for their continued participation.
Publisher Copyright:
© 2016 American Psychological Association.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Understanding how specific genes contribute to risk for addiction remains challenging. This study tests whether childhood temperament and externalizing behavior in early adolescence account for a portion of the association between specific genetic variants and substance use problems in late adolescence. The sample consisted of 487 adolescents from the Michigan Longitudinal Study, a high-risk sample (70.2% male, 81.7% European American ancestry). Polymorphisms across serotonergic (SLC6A4, 5-HTTLPR), dopaminergic (DRD4, u-VNTR), noradrenergic (SLC6A2, rs36021), and GABAergic (GABRA2, rs279858; GABRA6, rs3811995) genes were examined given prior support for associations with temperament, externalizing behavior, and substance use problems. The temperament traits behavioral control and resiliency were assessed using interviewer ratings (ages 9-11), and externalizing behavior (ages 12-14) was assessed using teacher ratings. Self-reported substance use outcomes (ages 15-17) included maximum alcoholic beverages consumed in 24 hours, and frequency of past year cigarette and marijuana use. Behavioral control, resiliency, and externalizing behavior accounted for the associations between polymorphisms in noradrenergic and GABAergic genes and substance use in late adolescence. Individual differences in emotional coping and behavioral regulation represent nonspecific neurobiological underpinnings for an externalizing pathway to addiction.
AB - Understanding how specific genes contribute to risk for addiction remains challenging. This study tests whether childhood temperament and externalizing behavior in early adolescence account for a portion of the association between specific genetic variants and substance use problems in late adolescence. The sample consisted of 487 adolescents from the Michigan Longitudinal Study, a high-risk sample (70.2% male, 81.7% European American ancestry). Polymorphisms across serotonergic (SLC6A4, 5-HTTLPR), dopaminergic (DRD4, u-VNTR), noradrenergic (SLC6A2, rs36021), and GABAergic (GABRA2, rs279858; GABRA6, rs3811995) genes were examined given prior support for associations with temperament, externalizing behavior, and substance use problems. The temperament traits behavioral control and resiliency were assessed using interviewer ratings (ages 9-11), and externalizing behavior (ages 12-14) was assessed using teacher ratings. Self-reported substance use outcomes (ages 15-17) included maximum alcoholic beverages consumed in 24 hours, and frequency of past year cigarette and marijuana use. Behavioral control, resiliency, and externalizing behavior accounted for the associations between polymorphisms in noradrenergic and GABAergic genes and substance use in late adolescence. Individual differences in emotional coping and behavioral regulation represent nonspecific neurobiological underpinnings for an externalizing pathway to addiction.
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U2 - 10.1037/abn0000143
DO - 10.1037/abn0000143
M3 - Article
C2 - 26845260
AN - SCOPUS:84973098174
SN - 0021-843X
VL - 125
SP - 565
EP - 575
JO - Journal of Abnormal Psychology
JF - Journal of Abnormal Psychology
IS - 4
ER -