Testing percutaneous arterial closure devices: An animal model

Rui Fang Ni, Pawanrat Kranokpiraksa, Dusan Pavcnik, Hideaki Kakizawa, Barry T. Uchida, Frederick S. Keller, Josef Rösch

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The ovine superficial femoral artery was used for testing the efficacy of percutaneous arterial closure devices (PACDs) in their developmental stage. Two topical devices containing chitostan, one staple-mediated PACD and a porcine small intestinal submucosa plug, were tested by follow-up angiography in 37 sheep. Absence or presence of bleeding and time to bleeding cessation were the main criteria for evaluation of PAVD efficacy. The results of these tests directed modification of individual PACDs and improved their efficacy.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalCardiovascular and interventional radiology
Issue number2
StatePublished - Mar 2009
Externally publishedYes


  • Animal model
  • Experimental device
  • Hemostasis
  • Percutaneous arterial procedures

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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