Testosterone replacement therapy and prostate health

A. Scott Polackwich, Kevin A. Ostrowski, Jason C. Hedges

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


There is an emerging evolution in the understanding of the relationship between the prostate and testosterone. It has long been generally believed that with testosterone replacement therapy (TRT), increasing serum testosterone levels led to prostatic growth and worsening of voiding dysfunction and associated complications. A new theory, the Saturation Model of Testosterone and its effect on the Prostate has gained attention. This theory suggests that the prostate's response to increasing levels of serum testosterone reaches a limit beyond which there is minimal effect. This model predicts that testosterone replacement therapy occurs above this saturation point, and replacing testosterone to eugonadal levels should not worsen prostate related benign disease. We evaluated the recent published data, with an emphasis on clinical studies done within the last 3 years, for the effects of testosterone supplementation on benign prostatic disease.

Original languageEnglish (US)
Pages (from-to)441-446
Number of pages6
JournalCurrent urology reports
Issue number6
StatePublished - Dec 2012


  • BPH
  • Benign prostatic hyperplasia, prostate volume, IPSS
  • LUTS
  • Lower urinary tract symptoms
  • PSA
  • Prostate
  • Prostate specific antigen
  • Testosterone replacement

ASJC Scopus subject areas

  • Urology


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