The antimicrobial and osteoinductive properties of silver nanoparticle/poly (dl-lactic-co-glycolic acid)-coated stainless steel

Yi Liu; Zhong Zheng; Janette N. Zara; Chingyun Hsu; Donnalisa E. Soofer; Kevin S. Lee; Ronald K. Siu; Lloyd S. Miller; Xinli Zhang; Doug Carpenter; Chunling Wang; Kang Ting; Chia Soo

doi:10.1016/j.biomaterials.2012.08.010

The antimicrobial and osteoinductive properties of silver nanoparticle/poly (dl-lactic-co-glycolic acid)-coated stainless steel

Yi Liu, Zhong Zheng, Janette N. Zara, Chingyun Hsu, Donnalisa E. Soofer, Kevin S. Lee, Ronald K. Siu, Lloyd S. Miller, Xinli Zhang, Doug Carpenter, Chunling Wang, Kang Ting, Chia Soo

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated silver nanoparticle/. poly (dl-lactic- co-glycolic acid) (PLGA)-coated stainless steel alloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.

Original language	English (US)
Pages (from-to)	8745-8756
Number of pages	12
Journal	Biomaterials
Volume	33
Issue number	34
DOIs	https://doi.org/10.1016/j.biomaterials.2012.08.010
State	Published - Dec 2012
Externally published	Yes

Keywords

Antimicrobial osteoinductive
Implant-associated infections
Poly(dl-lactic-co-glycolic acid) (PLGA)
Silver nanoparticle
Silver nanoparticle/poly(dl-lactic-co-glycolic acid)-coated stainless steel alloy (SNPSA)

ASJC Scopus subject areas

Mechanics of Materials
Ceramics and Composites
Bioengineering
Biophysics
Biomaterials

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10.1016/j.biomaterials.2012.08.010

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Liu, Y., Zheng, Z., Zara, J. N., Hsu, C., Soofer, D. E., Lee, K. S., Siu, R. K., Miller, L. S., Zhang, X., Carpenter, D., Wang, C., Ting, K., & Soo, C. (2012). The antimicrobial and osteoinductive properties of silver nanoparticle/poly (dl-lactic-co-glycolic acid)-coated stainless steel. Biomaterials, 33(34), 8745-8756. https://doi.org/10.1016/j.biomaterials.2012.08.010

@article{2b0f613651bf40d598b0cccd0403d361,

title = "The antimicrobial and osteoinductive properties of silver nanoparticle/poly (dl-lactic-co-glycolic acid)-coated stainless steel",

abstract = "Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated silver nanoparticle/. poly (dl-lactic- co-glycolic acid) (PLGA)-coated stainless steel alloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.",

keywords = "Antimicrobial osteoinductive, Implant-associated infections, Poly(dl-lactic-co-glycolic acid) (PLGA), Silver nanoparticle, Silver nanoparticle/poly(dl-lactic-co-glycolic acid)-coated stainless steel alloy (SNPSA)",

author = "Yi Liu and Zhong Zheng and Zara, {Janette N.} and Chingyun Hsu and Soofer, {Donnalisa E.} and Lee, {Kevin S.} and Siu, {Ronald K.} and Miller, {Lloyd S.} and Xinli Zhang and Doug Carpenter and Chunling Wang and Kang Ting and Chia Soo",

note = "Funding Information: This research is supported by the US DoD Grant 07128099 . Y. L. is supported by the China Scholarship Council (CSC). The authors would like to thank Dr. Wei Yuan from the Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China and Dr. Michael Chiang from the Dental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, University of California, Los Angeles for assistance in surgery and microCT scanning, and the Translational Pathology Core Laboratory (TPCL) and Surgical Pathology divisions of the UCLA Department of Pathology and Laboratory Medicine for histology processing. ",

year = "2012",

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doi = "10.1016/j.biomaterials.2012.08.010",

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AU - Liu, Yi

AU - Zheng, Zhong

AU - Zara, Janette N.

AU - Hsu, Chingyun

AU - Soofer, Donnalisa E.

AU - Lee, Kevin S.

AU - Siu, Ronald K.

AU - Miller, Lloyd S.

AU - Zhang, Xinli

AU - Carpenter, Doug

AU - Wang, Chunling

AU - Ting, Kang

AU - Soo, Chia

N1 - Funding Information: This research is supported by the US DoD Grant 07128099 . Y. L. is supported by the China Scholarship Council (CSC). The authors would like to thank Dr. Wei Yuan from the Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China and Dr. Michael Chiang from the Dental and Craniofacial Research Institute and Section of Orthodontics, School of Dentistry, University of California, Los Angeles for assistance in surgery and microCT scanning, and the Translational Pathology Core Laboratory (TPCL) and Surgical Pathology divisions of the UCLA Department of Pathology and Laboratory Medicine for histology processing.

PY - 2012/12

Y1 - 2012/12

N2 - Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated silver nanoparticle/. poly (dl-lactic- co-glycolic acid) (PLGA)-coated stainless steel alloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.

AB - Implant-associated bacterial infections are one of the most serious complications in orthopedic surgery. Treatment of these infections often requires multiple operations, device removal, long-term systemic antibiotics, and extended rehabilitation, and is frequently ineffective, leading to worse clinical outcomes and increased financial costs. In this study, we evaluated silver nanoparticle/. poly (dl-lactic- co-glycolic acid) (PLGA)-coated stainless steel alloy(SNPSA) as a potential antimicrobial implant material. We found that SNPSA exhibited strong antibacterial activity in vitro and ex vivo, and promoted MC3T3-E1 pre-osteoblasts proliferation and maturation in vitro. Furthermore, SNPSA implants induced osteogenesis while suppressing bacterial survival in contaminated rat femoral canals. Our results indicate that SNPSA has simultaneous antimicrobial and osteoinductive properties that make it a promising therapeutic material in orthopedic surgery.

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ER -

The antimicrobial and osteoinductive properties of silver nanoparticle/poly (dl-lactic-co-glycolic acid)-coated stainless steel

Abstract

Keywords

ASJC Scopus subject areas

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