Abstract
The HLA type of patients with various kinds of immune reactions to bovine collagen implants were evaluated to determine a possible genetic basis for such responses. All patients suffering adverse clinical reactions to bovine collagen implants were lacking the HLA-DR4 antigen. All patients who received multiple bovine collagen injections without having adverse clinical reactions were lacking HLA-B5 and HLA-DR5 and had a significantly increased incidence of HLA-DR4. Combinations of histocompatibility antigens may influence immune response to bovine collagen implants.
Original language | English (US) |
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Pages (from-to) | 650-654 |
Number of pages | 5 |
Journal | Archives of Dermatology |
Volume | 122 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1986 |
Externally published | Yes |
ASJC Scopus subject areas
- Dermatology