The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: Implications and effect of weight loss

Daniel R. Cottam, Samer G. Mattar, Emma Barinas-Mitchell, George Eid, Lewis Kuller, David E. Kelley, Philip R. Schauer

Research output: Contribution to journalReview articlepeer-review

362 Scopus citations


Background: Obesity is a worldwide pandemic that causes a multitude of co-morbid conditions. However, there has been slow progress in understanding the basic pathophysiology that underlies co-morbid conditions associated with obesity. Recently, there has been intense interest in the role of inflammation in obesity. Using the inflammatory hypothesis, many of the mechanisms by which co-morbid conditions are associated with obesity are being elucidated. Methods: We searched the literature and reviewed all relevant articles. We focused on hormones and cytokines that have been associated with other inflammatory conditions such as sepsis and systemic inflammatory response syndrome. Findings: Angiotensinogen (AGT), transforming growth factor beta (TGFβ), tumor necrosis factor alpha (TMFα), and interleukin six (IL-6) are all elevated in obesity and correlate with several markers of adipocyte mass. These mediators have detrimental effects on hypertension, diabetes, dyslipidemia, thromboembolic phenomena, infections, and cancer. Weight loss results in a reduction of inflammatory mediators and a diminution of the associated co-morbid conditions. Conclusions: The success of weight loss surgery in treating the complications associated with obesity is most probably related to the reduction of inflammatory mediators. While some aspects of bariatric physiology remain unclear, there appears to be a strong association between obesity and inflammation, thereby rendering obesity a chronic inflammatory state. A clearer understanding of the physiology of obesity will allow physicians who treat the obese to develop better strategies to promote weight loss and improve the well-being of millions of individuals.

Original languageEnglish (US)
Pages (from-to)589-600
Number of pages12
JournalObesity Surgery
Issue number5
StatePublished - May 2004
Externally publishedYes


  • Angiotensin
  • C-reactive protein
  • Cancer
  • Hypertension
  • Infection
  • Inflammation
  • Insulin resistance
  • Interleukin
  • Leptin
  • Morbid obesity
  • Obesity
  • Serum amyloid A
  • Transforming growth factor
  • Tumor necrosis factor

ASJC Scopus subject areas

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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