The clinical aspect of NTRK-fusions in pediatric papillary thyroid cancer

Julio C. Ricarte-Filho; Stephen Halada; Alison O'Neill; Victoria Casado-Medrano; Theodore W. Laetsch; Aime T. Franco; Andrew J. Bauer

doi:10.1016/j.cancergen.2022.01.002

The clinical aspect of NTRK-fusions in pediatric papillary thyroid cancer

Julio C. Ricarte-Filho, Stephen Halada, Alison O'Neill, Victoria Casado-Medrano, Theodore W. Laetsch, Aime T. Franco, Andrew J. Bauer

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Although adult and pediatric papillary thyroid cancer (PTC) share similar oncogenic drivers, they differ in the pathological features and outcomes of the disease. In adults with PTC, the most frequent genetic alterations are mutually exclusive point mutations in BRAF^V600E or the RAS family with BRAF^V600E commonly associated with invasive disease and decreased response to radioiodine therapy. In pediatric PTC, fusion oncogenes involving chromosomal translocations in tyrosine kinase (TK) receptors, most commonly RET and NTRK, are often found in patients with lateral neck and distant metastases. This brief report reviews clinical data from a single-institute's cohort of NTRK-driven pediatric PTC cases with an updated review of the literature and comparison to adult NTRK-driven PTC.

Original language	English (US)
Pages (from-to)	57-63
Number of pages	7
Journal	Cancer Genetics
Volume	262-263
DOIs	https://doi.org/10.1016/j.cancergen.2022.01.002
State	Published - Apr 2022
Externally published	Yes

Keywords

Adult thyroid cancer
NTRK fusion
Oncogene
Pediatric

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergen.2022.01.002

Cite this

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title = "The clinical aspect of NTRK-fusions in pediatric papillary thyroid cancer",

abstract = "Although adult and pediatric papillary thyroid cancer (PTC) share similar oncogenic drivers, they differ in the pathological features and outcomes of the disease. In adults with PTC, the most frequent genetic alterations are mutually exclusive point mutations in BRAFV600E or the RAS family with BRAFV600E commonly associated with invasive disease and decreased response to radioiodine therapy. In pediatric PTC, fusion oncogenes involving chromosomal translocations in tyrosine kinase (TK) receptors, most commonly RET and NTRK, are often found in patients with lateral neck and distant metastases. This brief report reviews clinical data from a single-institute's cohort of NTRK-driven pediatric PTC cases with an updated review of the literature and comparison to adult NTRK-driven PTC.",

keywords = "Adult thyroid cancer, NTRK fusion, Oncogene, Pediatric",

author = "Ricarte-Filho, {Julio C.} and Stephen Halada and Alison O'Neill and Victoria Casado-Medrano and Laetsch, {Theodore W.} and Franco, {Aime T.} and Bauer, {Andrew J.}",

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doi = "10.1016/j.cancergen.2022.01.002",

language = "English (US)",

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AU - Ricarte-Filho, Julio C.

AU - Halada, Stephen

AU - O'Neill, Alison

AU - Casado-Medrano, Victoria

AU - Laetsch, Theodore W.

AU - Franco, Aime T.

AU - Bauer, Andrew J.

PY - 2022/4

Y1 - 2022/4

N2 - Although adult and pediatric papillary thyroid cancer (PTC) share similar oncogenic drivers, they differ in the pathological features and outcomes of the disease. In adults with PTC, the most frequent genetic alterations are mutually exclusive point mutations in BRAFV600E or the RAS family with BRAFV600E commonly associated with invasive disease and decreased response to radioiodine therapy. In pediatric PTC, fusion oncogenes involving chromosomal translocations in tyrosine kinase (TK) receptors, most commonly RET and NTRK, are often found in patients with lateral neck and distant metastases. This brief report reviews clinical data from a single-institute's cohort of NTRK-driven pediatric PTC cases with an updated review of the literature and comparison to adult NTRK-driven PTC.

AB - Although adult and pediatric papillary thyroid cancer (PTC) share similar oncogenic drivers, they differ in the pathological features and outcomes of the disease. In adults with PTC, the most frequent genetic alterations are mutually exclusive point mutations in BRAFV600E or the RAS family with BRAFV600E commonly associated with invasive disease and decreased response to radioiodine therapy. In pediatric PTC, fusion oncogenes involving chromosomal translocations in tyrosine kinase (TK) receptors, most commonly RET and NTRK, are often found in patients with lateral neck and distant metastases. This brief report reviews clinical data from a single-institute's cohort of NTRK-driven pediatric PTC cases with an updated review of the literature and comparison to adult NTRK-driven PTC.

KW - Adult thyroid cancer

KW - NTRK fusion

KW - Oncogene

KW - Pediatric

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The clinical aspect of NTRK-fusions in pediatric papillary thyroid cancer

Abstract

Keywords

ASJC Scopus subject areas

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